Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells
Language: 
English
Abstract: 

Acetyl-keto-beta-boswellic acid (AKBA), a triterpenoid isolated from Boswellia carterri Birdw and Boswellia serrata, has been found to inhibit tumor cell growth and to induce apoptosis. The apoptotic effects and the mechanisms of action of AKBA were studied in LNCaP and PC-3 human prostate cancer cells. AKBA induced apoptosis in both cell lines at concentrations above 10 microg/mL. AKBA-induced apoptosis was correlated with the activation of caspase-3 and caspase-8 as well as with poly(ADP)ribose polymerase (PARP) cleavage. The activation of caspase-8 was correlated with increased levels of death receptor (DR) 5 but not of Fas or DR4. AKBA-induced apoptosis, caspase-8 activation, and PARP cleavage were inhibited by knocking down DR5 using a small hairpin RNA. AKBA treatment increased the levels of CAAT/enhancer binding protein homologous protein (CHOP) and activated a DR5 promoter reporter but did not activate a DR5 promoter reporter with the mutant CHOP binding site. These results suggest that AKBA induces apoptosis in prostate cancer cells through a DR5-mediated pathway, which probably involves the induced expression of CHOP.

Author(s): 
Lu, Min
Xia, Lijuan
Hua, Huiming
Jing, Yongkui
Item Type: 
Journal Article
Publication Title: 
Cancer Research
Journal Abbreviation: 
Cancer Res.
Publication Date: 
Feb 15, 2008
Publication Year: 
2008
Pages: 
1180-1186
Volume: 
68
Issue: 
4
ISSN: 
1538-7445
DOI: 
10.1158/0008-5472.CAN-07-2978
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 18281494

Turabian/Chicago Citation

Min Lu, Lijuan Xia, Huiming Hua and Yongkui Jing. Feb 15, 2008. "Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells." Cancer Research 68: 4: 1180-1186. 10.1158/0008-5472.CAN-07-2978.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1158/0008-5472.CAN-07-2978 | issn = 1538-7445 | volume = 68 | pages = 1180-1186 | last = Lu | first = Min | coauthors = Xia, Lijuan, Hua, Huiming, Jing, Yongkui | title = Acetyl-keto-beta-boswellic acid induces apoptosis through a death receptor 5-mediated pathway in prostate cancer cells | journal = Cancer Research | date = Feb 15, 2008 | pmid = | pmc = }} </ref>