Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection
Language: 
English
Abstract: 

In chronic infectious diseases, such as schistosomiasis, pathogen growth and immunopathology are affected by the induction of a proper balanced Th1/Th2 response to the pathogen and by antigen-triggered activation-induced T cell death. Here, by using S. japonicum infection or schistosome antigens-immunized mouse model, or antigens in vitro stimulation, we report that during the early stage of S. japonicum infection, nonegg antigens trigger Th2 cell apoptosis via the granzyme B signal pathway, contributing to Th1 polarization, which is thought to be associated with worm clearance and severe schistosomiasis. Meanwhile, after the adult worms lay their eggs, the egg antigens trigger Th1 cell apoptosis via the caspase pathway, contributing to Th2 polarization, which is associated with mild pathology and enhanced survival of both worms and their hosts. Thus, our study suggests that S. japonicum antigen-induced Th1 and Th2 cell apoptosis involves the Th1/Th2 shift and favorites both hosts and parasites.

Author(s): 
Xu, Xinyu
Wen, Xiaoyun
Chi, Ying
He, Lei
Zhou, Sha
Wang, Xuefeng
Zhao, Jiaqing
Liu, Feng
Su, Chuan
Item Type: 
Journal Article
Publication Title: 
Journal of Biomedicine & Biotechnology
Journal Abbreviation: 
J. Biomed. Biotechnol.
Publication Date: 
2010
Publication Year: 
2010
Pages: 
202397
Volume: 
2010
ISSN: 
1110-7251
DOI: 
10.1155/2010/202397
Library Catalog: 
PubMed
Extra: 
PMID: 20111738 PMCID: PMC2810471

Turabian/Chicago Citation

Xinyu Xu, Xiaoyun Wen, Ying Chi, Lei He, Sha Zhou, Xuefeng Wang, Jiaqing Zhao, Feng Liu and Chuan Su. 2010. "Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection." Journal of Biomedicine & Biotechnology 2010: 202397. 10.1155/2010/202397.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1155/2010/202397 | issn = 1110-7251 | volume = 2010 | pages = 202397 | last = Xu | first = Xinyu | coauthors = Wen, Xiaoyun, Chi, Ying, He, Lei, Zhou, Sha, Wang, Xuefeng, Zhao, Jiaqing, Liu, Feng, Su, Chuan | title = Activation-induced T helper cell death contributes to Th1/Th2 polarization following murine Schistosoma japonicum infection | journal = Journal of Biomedicine & Biotechnology | date = 2010 | pmid = | pmc = }} </ref>