Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson's disease

BACKGROUND: Acupuncture is increasingly used as an additional treatment for patients with Parkinson's disease (PD). METHODS: In this functional magnetic resonance imaging study, brain activation in response to acupuncture in a group of 12 patients with PD was compared with a group of 12 healthy participants. Acupuncture was conducted on a specific acupoint, the right GB 34 (Yanglingquan), which is a frequently used acupoint for motor function treatment in the oriental medical field. RESULTS: Acupuncture stimulation on this acupoint activates the prefrontal cortex, precentral gyrus, and putamen in patients with PD; areas that are known to be impaired in patients with PD. Compared with healthy participants, patients with PD showed significantly higher brain activity in the prefrontal cortex and precentral gyrus, especially visible in the left hemisphere. CONCLUSIONS: The neuroimaging results of our study suggest that in future acupuncture research; the prefrontal cortex as well as the precentral gyrus should be treated for symptoms of Parkinson's disease and that GB 34 seems to be a suitable acupoint. Moreover, acupuncture evoked different brain activations in patients with Parkinson's disease than in healthy participants in our study, stressing the importance of conducting acupuncture studies on both healthy participants as well as patients within the same study, in order to detect acupuncture efficacy. TRIAL REGISTRATION: KCT0001122 at (registration date: 20140530).

Yeo, Sujung
Choe, Il-Hwan
van den Noort, Maurits
Bosch, Peggy
Jahng, Geon-Ho
Rosen, Bruce
Kim, Sung-Hoon
Lim, Sabina
Item Type: 
Journal Article
Publication Title: 
BMC complementary and alternative medicine
Journal Abbreviation: 
BMC Complement Altern Med
Publication Date: 
Publication Year: 
Library Catalog: 
NCBI Published Medical (?)
PMID: 25220656 PMCID: PMC4175221

Turabian/Chicago Citation

Sujung Yeo, Il-Hwan Choe, Maurits van den Noort, Peggy Bosch, Geon-Ho Jahng, Bruce Rosen, Sung-Hoon Kim and Sabina Lim. 2014. "Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson's disease." BMC complementary and alternative medicine 14: 336. 10.1186/1472-6882-14-336.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1186/1472-6882-14-336 | issn = 1472-6882 | volume = 14 | pages = 336 | last = Yeo | first = Sujung | coauthors = Choe, Il-Hwan, van den Noort, Maurits, Bosch, Peggy, Jahng, Geon-Ho, Rosen, Bruce, Kim, Sung-Hoon, Lim, Sabina | title = Acupuncture on GB34 activates the precentral gyrus and prefrontal cortex in Parkinson's disease | journal = BMC complementary and alternative medicine | date = 2014 | pmid = | pmc = }} </ref>