Acute and sub-chronic toxicity of Tri-sa-maw recipe in rats
Language: 
English
Abstract: 

BACKGROUND: Tri-sa-maw recipe is a botanical preparation comprised of equal proportions ofthe three herbalfruits, namely Terminalia chebula Retz., Tenninalia sp. and Terminalia bellirica Roxb. This recipe is used for antipyretic, expectorant, periodic maintenance, and relieving stomach tight. OBJECTIVE: To evaluate the acute and sub-chronic toxicities of Tri-sa-maw recipe extract in rats. MATERIAL AND METHOD: In the present study of acute toxicity, a single oral dose 5,000 mg/kg of Tri-sa-maw recipe extract was administered to rats. Sub-chronic toxicity was studied by the daily oral administration ofthe extract at the doses of 600, 1,200 and 2,400 mg/kg body weight for consecutive 90 days. RESULTS: Tri-sa-maw recipe extract at the dose of 5,000 mg/kg showed no signs of differences as compared to the control rat. No abnormalities were found in the sub-chronic toxicity study; none of the parametersfor body and organ weights, hematol- ogy, blood chemistry, necropsy, and histopathology showed any differences between the control and all treatment groups. CONCLUSION: Tri-sa-maw recipe extract did not significantly cause acute toxicity or sub-chronic toxicity in rats.

Author(s): 
Nanna, Urarat
Jaijoy, Kanjana
Lertprasertsuke, Nirush
Soonthornchareonnon, Noppamas
Sireeratawong, Seewaboon
Item Type: 
Journal Article
Publication Title: 
Journal of the Medical Association of Thailand = Chotmaihet Thangphaet
Journal Abbreviation: 
J Med Assoc Thai
Publication Date: 
2015-03
Publication Year: 
2015
Pages: 
S8-15
Volume: 
98 Suppl 2
ISSN: 
0125-2208
Library Catalog: 
PubMed
Extra: 
PMID: 26211098

Turabian/Chicago Citation

Urarat Nanna, Kanjana Jaijoy, Nirush Lertprasertsuke, Noppamas Soonthornchareonnon and Seewaboon Sireeratawong. 2015-03. "Acute and sub-chronic toxicity of Tri-sa-maw recipe in rats." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet 98 Suppl 2: S8-15.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0125-2208 | volume = 98 Suppl 2 | pages = S8-15 | last = Nanna | first = Urarat | coauthors = Jaijoy, Kanjana, Lertprasertsuke, Nirush, Soonthornchareonnon, Noppamas, Sireeratawong, Seewaboon | title = Acute and sub-chronic toxicity of Tri-sa-maw recipe in rats | journal = Journal of the Medical Association of Thailand = Chotmaihet Thangphaet | date = 2015-03 | pmid = | pmc = }} </ref>