Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids
Language: 
English
Abstract: 

Environmental stressors during childhood and adolescence influence postnatal brain maturation and human behavioral patterns in adulthood. Accordingly, excess stressors result in adult-onset neuropsychiatric disorders. We describe an underlying mechanism in which glucocorticoids link adolescent stressors to epigenetic controls in neurons. In a mouse model of this phenomenon, a mild isolation stress affects the mesocortical projection of dopaminergic neurons in which DNA hypermethylation of the tyrosine hydroxylase gene is elicited, but only when combined with a relevant genetic risk for neuropsychiatric disorders. These molecular changes are associated with several neurochemical and behavioral deficits that occur in this mouse model, all of which are blocked by a glucocorticoid receptor antagonist. The biology and phenotypes of the mouse models resemble those of psychotic depression, a common and debilitating psychiatric disease.

Author(s): 
Niwa, Minae
Jaaro-Peled, Hanna
Tankou, Stephanie
Seshadri, Saurav
Hikida, Takatoshi
Matsumoto, Yurie
Cascella, Nicola G.
Kano, Shin-ichi
Ozaki, Norio
Nabeshima, Toshitaka
Sawa, Akira
Item Type: 
Journal Article
Publication Title: 
Science (New York, N.Y.)
Journal Abbreviation: 
Science
Publication Date: 
1/18/2013
Publication Year: 
2013
Pages: 
335-339
Volume: 
339
Issue: 
6117
ISSN: 
1095-9203
DOI: 
10.1126/science.1226931
Library Catalog: 
PubMed
Extra: 
PMID: 23329051 PMCID: PMC3617477

Turabian/Chicago Citation

Minae Niwa, Hanna Jaaro-Peled, Stephanie Tankou, Saurav Seshadri, Takatoshi Hikida, Yurie Matsumoto, Nicola G. Cascella, Shin-ichi Kano, Norio Ozaki, Toshitaka Nabeshima and Akira Sawa. 1/18/2013. "Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids." Science (New York, N.Y.) 339: 6117: 335-339. 10.1126/science.1226931.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1126/science.1226931 | issn = 1095-9203 | volume = 339 | pages = 335-339 | last = Niwa | first = Minae | coauthors = Jaaro-Peled, Hanna, Tankou, Stephanie, Seshadri, Saurav, Hikida, Takatoshi, Matsumoto, Yurie, Cascella, Nicola G., Kano, Shin-ichi, Ozaki, Norio, Nabeshima, Toshitaka, Sawa, Akira | title = Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids | journal = Science (New York, N.Y.) | date = 1/18/2013 | pmid = | pmc = }} </ref>