Advances in endocrinology of aging research, 2005-2006
Language: 
English
Abstract: 

The purpose of this brief review is to highlight some of the more important advances in endocrinology of aging research over the past year. Four advances were chosen and briefly described. First, exploration of the early steps in the generation of the internal steroidal hormonal signal involved in lifespan extension via the insulin/IGF-like signaling pathway in the nematode by two research groups revealed that the product of cholestanoic acid derivatives metabolized by a cytochrome P-450-like protein activates a protein with homology to the mammalian nuclear receptor superfamily, a process strikingly similar to the steroid hormone signaling pathway documented in mammalian systems. Second is the discovery that sirtuins, proteins that regulate lifespan in model organisms, enhance pancreatic insulin secretion in mice following a glucose challenge, suggesting the potential to regulate mammalian lifespan through regulation of the insulin signaling pathway. Third, the newly discovered hormone klotho, which also plays a role in regulating lifespan, in this case in mice, is reported to not only negatively affect insulin sensitivity but, perhaps more importantly, significantly affects calcium and phosphate metabolism as a required cofactor of Fgf-23 signaling. Finally the gonadotropin FSH is shown to directly affect bone density in mice separate from any direct effect of estrogen, suggesting that reproductive hormones other than estrogen can directly impact menopause-associated pathophysiology in non-reproductive tissues.

Author(s): 
Bellino, Francis L.
Item Type: 
Journal Article
Publication Title: 
Experimental Gerontology
Journal Abbreviation: 
Exp. Gerontol.
Publication Date: 
2006-12
Publication Year: 
2006
Pages: 
1228-1233
Volume: 
41
Issue: 
12
ISSN: 
0531-5565
DOI: 
10.1016/j.exger.2006.09.007
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 17110071 PMCID: PMC1804294

Turabian/Chicago Citation

Francis L. Bellino. 2006-12. "Advances in endocrinology of aging research, 2005-2006." Experimental Gerontology 41: 12: 1228-1233. 10.1016/j.exger.2006.09.007.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.exger.2006.09.007 | issn = 0531-5565 | volume = 41 | pages = 1228-1233 | last = Bellino | first = Francis L. | coauthors = | title = Advances in endocrinology of aging research, 2005-2006 | journal = Experimental Gerontology | date = 2006-12 | pmid = | pmc = }} </ref>