Age-associated alteration in naive and memory Th17 cell response in humans
Language: 
English
Abstract: 

Th17 cells produce IL-17 that plays an important role in host defense. However, little is known about whether aging affects human Th17 cells. Here we demonstrated that healthy elderly people (age ≥ 65) had a decreased frequency of IL-17-producing cells in memory CD4(+) T cells compared to healthy young people (age ≤ 40) while both groups had similar frequencies of IFN-γ-producing cells in the same memory cell subset as measured by flow cytometry. In contrast, the healthy elderly had increased differentiation of IL-17-producing effector cells but not IFN-γ-producing cells from naive CD4(+) T cells compared to the healthy young. The results of ELISA also showed similar findings with increased IL-17 production from naive CD4(+) T cells and decreased IL-17 production from memory CD4(+) T cells in the elderly compared to the young. These findings indicate that aging differentially affects naive and memory Th17 cell responses in humans.

Author(s): 
Lee, Jin Soo
Lee, Won-Woo
Kim, Sang Hyun
Kang, Youna
Lee, Naeun
Shin, Min Sun
Kang, Seong Wook
Kang, Insoo
Item Type: 
Journal Article
Publication Title: 
Clinical Immunology (Orlando, Fla.)
Journal Abbreviation: 
Clin. Immunol.
Publication Date: 
Jul 2011
Publication Year: 
2011
Pages: 
84-91
Volume: 
140
Issue: 
1
ISSN: 
1521-7035
DOI: 
10.1016/j.clim.2011.03.018
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 21489886 PMCID: PMC3115516

Turabian/Chicago Citation

Jin Soo Lee, Won-Woo Lee, Sang Hyun Kim, Youna Kang, Naeun Lee, Min Sun Shin, Seong Wook Kang and Insoo Kang. Jul 2011. "Age-associated alteration in naive and memory Th17 cell response in humans." Clinical Immunology (Orlando, Fla.) 140: 1: 84-91. 10.1016/j.clim.2011.03.018.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.clim.2011.03.018 | issn = 1521-7035 | volume = 140 | pages = 84-91 | last = Lee | first = Jin Soo | coauthors = Lee, Won-Woo, Kim, Sang Hyun, Kang, Youna, Lee, Naeun, Shin, Min Sun, Kang, Seong Wook, Kang, Insoo | title = Age-associated alteration in naive and memory Th17 cell response in humans | journal = Clinical Immunology (Orlando, Fla.) | date = Jul 2011 | pmid = | pmc = }} </ref>