Aging and survival: the genetics of life span extension by dietary restriction
Language: 
English
Short Title: 
Aging and survival
Abstract: 

Reducing food intake to induce undernutrition but not malnutrition extends the life spans of multiple species, ranging from single-celled organisms to mammals. This increase in longevity by dietary restriction (DR) is coupled to profound beneficial effects on age-related pathology. Historically, much of the work on DR has been undertaken using rodent models, and 70 years of research has revealed much about the physiological changes DR induces. However, little is known about the genetic pathways that regulate the DR response and whether or not they are conserved between species. Elucidating these pathways may facilitate the design of targeted pharmaceutical treatments for a range of age-related pathologies. Here, we discuss how recent work in nonmammalian model organisms has revealed new insight into the genetics of DR and how the discovery of DR-specific transcription factors will advance our understanding of this phenomenon.

Author(s): 
Mair, William
Dillin, Andrew
Item Type: 
Journal Article
Publication Title: 
Annual Review of Biochemistry
Journal Abbreviation: 
Annu. Rev. Biochem.
Publication Date: 
2008
Publication Year: 
2008
Pages: 
727-754
Volume: 
77
ISSN: 
0066-4154
DOI: 
10.1146/annurev.biochem.77.061206.171059
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 18373439

Turabian/Chicago Citation

William Mair and Andrew Dillin. 2008. "Aging and survival: the genetics of life span extension by dietary restriction." Annual Review of Biochemistry 77: 727-754. 10.1146/annurev.biochem.77.061206.171059.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1146/annurev.biochem.77.061206.171059 | issn = 0066-4154 | volume = 77 | pages = 727-754 | last = Mair | first = William | coauthors = Dillin, Andrew | title = Aging and survival: the genetics of life span extension by dietary restriction | journal = Annual Review of Biochemistry | date = 2008 | pmid = | pmc = }} </ref>