American ginseng inhibits vascular smooth muscle cell proliferation via suppressing Jak/Stat pathway
Language: 
English
Abstract: 

ETHNOPHARMCOLOGICAL RELEVANCE: Ginseng, a folk medicine which has been used for thousands of years in Asia, has been promoted for the treatment or prevention of health problems including cardiovascular disease. However, the molecular mechanism of ginseng-induced cardiovascular protection is unclear. Thus, we investigated signaling mechanism by which American ginseng inhibits vascular smooth muscle cell (VSMC) proliferation, a key feature of diverse vascular disease. MATERIALS AND METHODS: A standardized crude extract of American ginseng was supplied by the National Research Council of Canada, Institute for National Measurement Standards. Rat aortic smooth muscle cells (RASMCs) were exposed to fetal bovine serum (FBS), platelet derived growth factor (PDGF), insulin, or angiotensin II (Ang II) to induce proliferation that was examined by measuring DNA synthesis and cell numbers. Western blot was applied to determine the activations of Jak, Stat, Akt, and ERK. RESULTS: American ginseng inhibited RASMC proliferation induced by FBS, PDGF, insulin or Ang II. American ginseng slightly increased both basal and FBS-, PDGF- or Ang II-induced activities of Akt and ERK in RASMCs; however, it dramatically inhibited the activation of Jak2 and Stat3. CONCLUSION: These results demonstrate that American ginseng inhibits VSMC proliferation through suppressing the Jak/Stat pathway.

Author(s): 
Wu, Qi
Wang, Wenjuan
Li, Siying
Nagarkatti, Prakash
Nagarkatti, Mitzi
Windust, Anthony
Wang, Xing Li
Tang, Dongqi
Cui, Taixing
Item Type: 
Journal Article
Publication Title: 
Journal of Ethnopharmacology
Journal Abbreviation: 
J Ethnopharmacol
Publication Date: 
Dec 18, 2012
Publication Year: 
2012
Pages: 
782-785
Volume: 
144
Issue: 
3
ISSN: 
1872-7573
DOI: 
10.1016/j.jep.2012.09.046
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23041701 PMCID: PMC4109065

Turabian/Chicago Citation

Qi Wu, Wenjuan Wang, Siying Li, Prakash Nagarkatti, Mitzi Nagarkatti, Anthony Windust, Xing Li Wang, Dongqi Tang and Taixing Cui. Dec 18, 2012. "American ginseng inhibits vascular smooth muscle cell proliferation via suppressing Jak/Stat pathway." Journal of Ethnopharmacology 144: 3: 782-785. 10.1016/j.jep.2012.09.046.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.jep.2012.09.046 | issn = 1872-7573 | volume = 144 | pages = 782-785 | last = Wu | first = Qi | coauthors = Wang, Wenjuan, Li, Siying, Nagarkatti, Prakash, Nagarkatti, Mitzi, Windust, Anthony, Wang, Xing Li, Tang, Dongqi, Cui, Taixing | title = American ginseng inhibits vascular smooth muscle cell proliferation via suppressing Jak/Stat pathway | journal = Journal of Ethnopharmacology | date = Dec 18, 2012 | pmid = | pmc = }} </ref>