Analysis of drugs illegally added into Chinese traditional patent medicine using surface-enhanced Raman scattering
Language: 
English
Abstract: 

Illegal chemicals, which could cause unpredictable side effects, may be added into traditional Chinese medicine (TCM) for a rapid healing effect. In this report, a surface-enhanced Raman scattering (SERS) analysis method for five kinds of illegally added drugs (rosiglitazone maleate, phenformin hydrochloride, metformin hydrochloride, pioglitazone hydrochloride and sibutramine hydrochloride) in Chinese traditional patent medicine (CTPM) has been demonstrated, including simultaneous detections of drug mixtures with CTPM. Silver colloidal, prepared by a sodium citrate reaction, was used as a SERS substrate. The optimum pH condition for each drug has also been explored because of its combined effect on protonation, surface charge, repulsion of an analyte and nanoparticles. Furthermore, the simultaneous detection of two or three kinds of these chemicals has been carried out. Characteristic peaks are employed for qualitative analysis. This is the first research using SERS for the analysis of drug mixtures in CTPM without any separation process.

Author(s): 
Zhang, Yan
Huang, Xiaoyan
Liu, Wenfang
Cheng, Zeneng
Chen, Chuanpin
Yin, Lihui
Item Type: 
Journal Article
Publication Title: 
Analytical Sciences: The International Journal of the Japan Society for Analytical Chemistry
Journal Abbreviation: 
Anal Sci
Publication Date: 
2013
Publication Year: 
2013
Pages: 
985-990
Volume: 
29
Issue: 
10
ISSN: 
1348-2246
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 24107564

Turabian/Chicago Citation

Yan Zhang, Xiaoyan Huang, Wenfang Liu, Zeneng Cheng, Chuanpin Chen and Lihui Yin. 2013. "Analysis of drugs illegally added into Chinese traditional patent medicine using surface-enhanced Raman scattering." Analytical Sciences: The International Journal of the Japan Society for Analytical Chemistry 29: 10: 985-990.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1348-2246 | volume = 29 | pages = 985-990 | last = Zhang | first = Yan | coauthors = Huang, Xiaoyan, Liu, Wenfang, Cheng, Zeneng, Chen, Chuanpin, Yin, Lihui | title = Analysis of drugs illegally added into Chinese traditional patent medicine using surface-enhanced Raman scattering | journal = Analytical Sciences: The International Journal of the Japan Society for Analytical Chemistry | date = 2013 | pmid = | pmc = }} </ref>