The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically
Language: 
English
Abstract: 

Caloric restriction (CR) and a reduced growth hormone (GH)-insulin-like growth factor (IGF-1) axis are associated with an extension of lifespan across taxa. Evidence is reviewed showing that CR and reduced insulin of GH-IGF-1 axis may exhibit their effects at least partly by their common stimulatory action on autophagy, the cell repair mechanism responsible for the housekeeping of cell membranes and organelles including the free radical generators peroxisomes and mitochondria. It is shown that the life-long weekly administration of an anti-lipolytic drug may decrease glucose and insulin levels and stimulate autophagy and intensify anti-ageing effects of submaximal CR.

Author(s): 
Bergamini, E.
Cavallini, G.
Donati, A.
Gori, Z.
Item Type: 
Journal Article
Publication Title: 
Biomedicine & Pharmacotherapy = BiomÈdecine & PharmacothÈrapie
Journal Abbreviation: 
Biomed. Pharmacother.
Publication Date: 
2003-08
Publication Year: 
2003
Pages: 
203-208
Volume: 
57
Issue: 
6-May
ISSN: 
0753-3322
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 12888255

Turabian/Chicago Citation

E. Bergamini, G. Cavallini, A. Donati and Z. Gori. 2003-08. "The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically." Biomedicine & Pharmacotherapy = BiomÈdecine & PharmacothÈrapie 57: 6-May: 203-208.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0753-3322 | volume = 57 | pages = 203-208 | last = Bergamini | first = E. | coauthors = Cavallini, G., Donati, A., Gori, Z. | title = The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically | journal = Biomedicine & Pharmacotherapy = BiomÈdecine & PharmacothÈrapie | date = 2003-08 | pmid = | pmc = }} </ref>