Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling
Language: 
English
Short Title: 
Anti-aging effects of caloric restriction
Abstract: 

Many hormonal signals from peripheral tissues contribute to the regulation of energy homeostasis and food intake. These regulators including leptin, insulin, and ghrelin, modulate the orexigenic and anorexigenic neuropeptide expression in hypothalamic nuclei. The anti-aging effects of caloric restriction have been explained from an evolutional viewpoint of the adaptive response of the neuroendocrine and metabolic response systems to maximize survival during periods of food shortage. In organisms, excess energy is stored in adipose tissues as a triglyceride preparation for such survival situations. Adipose tissue has recently been recognized as an endocrine organ, and leptin, as secreted by adipocyte, seems to be an especially important factor for the adaptive response to fasting and neuroendocrine alterations under caloric restriction. In this review, we discuss the potential involvement of neuroendocrine modulators in longevity and the anti-aging effects of caloric restriction.

Author(s): 
Chiba, Takuya
Yamaza, Haruyoshi
Higami, Yoshikazu
Shimokawa, Isao
Item Type: 
Journal Article
Publication Title: 
Microscopy Research and Technique
Journal Abbreviation: 
Microsc. Res. Tech.
Publication Date: 
11/15/2002
Publication Year: 
2002
Pages: 
317-324
Volume: 
59
Issue: 
4
ISSN: 
1059-910X
DOI: 
10.1002/jemt.10211
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 12424795

Turabian/Chicago Citation

Takuya Chiba, Haruyoshi Yamaza, Yoshikazu Higami and Isao Shimokawa. 11/15/2002. "Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling." Microscopy Research and Technique 59: 4: 317-324. 10.1002/jemt.10211.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1002/jemt.10211 | issn = 1059-910X | volume = 59 | pages = 317-324 | last = Chiba | first = Takuya | coauthors = Yamaza, Haruyoshi, Higami, Yoshikazu, Shimokawa, Isao | title = Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling | journal = Microscopy Research and Technique | date = 11/15/2002 | pmid = | pmc = }} </ref>