Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model
Language: 
English
Abstract: 

The fruit of Terminalia chebula Retzius has been used as a panacea in India and Southeast Asia but its biological activities have not been fully elucidated. Here we report anti-arthritic and analgesic effect of NDI10218, a standardized ethanol extract of Terminalia chebula, on collagen-induced arthritis and acetic acid-induced writhing model, respectively. Arthritis was induced in DBA/1J mice by immunizing bovine type II collagen and mice were treated with NDI10218 daily for 5 weeks after the onset of the disease. NDI10218 reduced the arthritis index and blocked the synovial hyperplasia in a dose-dependent manner. The serum levels of pro-inflammatory cytokines TNF-?, IL-6, and IL-1? were significantly reduced in mice treated with NDI10218. Production of the inflammatory IL-17, but not immunosuppressive IL-10, was also inhibited in splenocytes isolated from NDI10218-treated arthritis mice. Administration of NDI10218 markedly decreased the number of T cell subpopulations in the regional lymph nodes of the arthritis mice. Finally, NDI10218 reduced the number of abdominal contractions in acetic acid-induced writhing model, suggesting an analgesic effect of this extract. Taken together, these results suggest that NDI10218 can be a new therapeutic candidate for the treatment of rheuma-toid arthritis.

Author(s): 
Seo, Jong Bae
Jeong, Jae-Yeon
Park, Jae Young
Jun, Eun Mi
Lee, Sang-Ik
Choe, Sung Sik
Park, Do-Yang
Choi, Eun-Wook
Seen, Dong-Seung
Lim, Jong-Soon
Lee, Tae Gyu
Item Type: 
Journal Article
Publication Title: 
Biomolecules & Therapeutics
Journal Abbreviation: 
Biomol Ther (Seoul)
Publication Date: 
2012-01
Publication Year: 
2012
Pages: 
104-112
Volume: 
20
Issue: 
1
ISSN: 
1976-9148
DOI: 
10.4062/biomolther.2012.20.1.104
Library Catalog: 
PubMed
Extra: 
PMID: 24116282 PMCID: PMC3792193

Turabian/Chicago Citation

Jong Bae Seo, Jae-Yeon Jeong, Jae Young Park, Eun Mi Jun, Sang-Ik Lee, Sung Sik Choe, Do-Yang Park, Eun-Wook Choi, Dong-Seung Seen, Jong-Soon Lim and Tae Gyu Lee. 2012-01. "Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model." Biomolecules & Therapeutics 20: 1: 104-112. 10.4062/biomolther.2012.20.1.104.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.4062/biomolther.2012.20.1.104 | issn = 1976-9148 | volume = 20 | pages = 104-112 | last = Seo | first = Jong Bae | coauthors = Jeong, Jae-Yeon, Park, Jae Young, Jun, Eun Mi, Lee, Sang-Ik, Choe, Sung Sik, Park, Do-Yang, Choi, Eun-Wook, Seen, Dong-Seung, Lim, Jong-Soon, Lee, Tae Gyu | title = Anti-Arthritic and Analgesic Effect of NDI10218, a Standardized Extract of Terminalia chebula, on Arthritis and Pain Model | journal = Biomolecules & Therapeutics | date = 2012-01 | pmid = | pmc = }} </ref>