Anti-inflammatory and antimicrobial properties of pyrroloquinazoline alkaloids from Adhatoda vasica Nees
Language: 
English
Abstract: 

Adhatoda vasica Nees, Acanthaceae, is well known plant in Ayurveda and Unani medicine. The purpose of this study was to characterize the most bioactive phytochemicals viz., vasicine, vasicinone, vasicine acetate, 2-acetyl benzyl amine, vasicinolone present in the chloroform fraction having anti-inflammatory and antimicrobial activities. The anti-inflammatory activity was tested by using carrageenan and CFA-model induced paw oedema. The antimicrobial activity of isolated compounds was assessed by using the microdilution method. The observed results revealed that vasicine showed most potent anti-inflammatory effects (59.51%) at the dose of 20.0mg/kg at 6h after carrageenan injection and maximum inhibition rate was observed of vasicinone (63.94%) at the dose of 10.0mg/kg at 4 days after CFA injection. The strong antibacterial activity was exhibited by vasicine at 20μg/ml dose against E. coli and also demonstrated maximum antifungal activity against C. albicans at the dose of >55μg/ml. All the five alkaloids demonstrated significant anti-inflammatory and antimicrobial activities.

Author(s): 
Singh, Bharat
Sharma, Ram Avtar
Item Type: 
Journal Article
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Journal Abbreviation: 
Phytomedicine
Publication Date: 
Mar 15, 2013
Publication Year: 
2013
Pages: 
441-445
Volume: 
20
Issue: 
5
ISSN: 
1618-095X
DOI: 
10.1016/j.phymed.2012.12.015
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23357363

Turabian/Chicago Citation

Bharat Singh and Ram Avtar Sharma. Mar 15, 2013. "Anti-inflammatory and antimicrobial properties of pyrroloquinazoline alkaloids from Adhatoda vasica Nees." Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 20: 5: 441-445. 10.1016/j.phymed.2012.12.015.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.phymed.2012.12.015 | issn = 1618-095X | volume = 20 | pages = 441-445 | last = Singh | first = Bharat | coauthors = Sharma, Ram Avtar | title = Anti-inflammatory and antimicrobial properties of pyrroloquinazoline alkaloids from Adhatoda vasica Nees | journal = Phytomedicine: International Journal of Phytotherapy and Phytopharmacology | date = Mar 15, 2013 | pmid = | pmc = }} </ref>