Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS -SLE (depression)
Language: 
English
Abstract: 

Systemic lupus erythematosus (SLE) is an autoimmune disease associated with more than 100 different autoantibodies, some of which may be associated with specific neuropsychiatric (NPSLE) manifestations. Injection of anti-P ribosomal antibodies (anti-P) directly to the brain ventricles of mice induces depression manifested by increased immobility time in the forced swim test (FST). METHODS: Mice were injected intracerebroventricularily (ICV) with affinity-purified human anti-P antibodies or normal commercial IgG as control. Mice were examined for depression by the forced swimming test (FST) and for olfactory function by the smell threshold test. Treatments included the antidepressant drug fluoxetine or aroma therapy by exposure to lemon or cinnamon odor. RESULTS: Mice injected with anti-P developed depression-like behavior, which improved significantly upon treatment with fluoxetine. Depressed mice had a significant deficit in olfactory function which was not reversed by fluoxetine. Exposure of anti-P-injected mice to lemon odor was associated with some improvement of the immobility time, a measure of depression. CONCLUSIONS: ICV injection of anti-P induces both depression-like behavior and impaired olfactory function in mice. Fluoxetine and possibly lemon odor exposure improve depressive behavior in these mice.

Author(s): 
Katzav, Aviva
Ben-Ziv, Tal
Chapman, Joab
Blank, Miri
Reichlin, Morris
Shoenfeld, Yehuda
Item Type: 
Journal Article
Publication Title: 
Journal of Autoimmunity
Journal Abbreviation: 
J. Autoimmun.
Publication Date: 
12/8/2015
Publication Year: 
2008
Pages: 
393-398
Volume: 
31
Issue: 
4
ISSN: 
0896-8411
DOI: 
10.1016/j.jaut.2008.09.002
Library Catalog: 
PubMed
Extra: 
PMID: 18947972

Turabian/Chicago Citation

Aviva Katzav, Tal Ben-Ziv, Joab Chapman, Miri Blank, Morris Reichlin and Yehuda Shoenfeld. 12/8/2015. "Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS -SLE (depression)." Journal of Autoimmunity 31: 4: 393-398. 10.1016/j.jaut.2008.09.002.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.jaut.2008.09.002 | issn = 0896-8411 | volume = 31 | pages = 393-398 | last = Katzav | first = Aviva | coauthors = Ben-Ziv, Tal, Chapman, Joab, Blank, Miri, Reichlin, Morris, Shoenfeld, Yehuda | title = Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS -SLE (depression) | journal = Journal of Autoimmunity | date = 12/8/2015 | pmid = | pmc = }} </ref>