Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers
Language: 
English
Abstract: 

In continuation of our drug discovery program on Indian medicinal plants, the gastro protective mechanism of chebulinic acid isolated from Terminalia chebula fruit was investigated. Chebulinic acid was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity of chebulinic acid was observed against CRU (62.9%), AS (55.3%), AL (80.67%) and PL (66.63%) induced ulcer models. The reference drug omeprazole (10 mg/kg, p.o.) showed 77.73% protection against CRU, 58.30% against AS and 70.80% against PL model. Sucralfate, another reference drug (500 mg/kg, p.o.) showed 65.67% protection in AL induced ulcer model. Chebulinic acid significantly reduced free acidity (48.82%), total acidity (38.29%) and upregulated mucin secretion by 59.75% respectively. Further, chebulinic acid significantly inhibited H(+) K(+)-ATPase activity in vitro with IC50 of 65.01 ?g/ml as compared to the IC50 value of omeprazole (30.24 ?g/ml) confirming its anti-secretory activity.

Author(s): 
Mishra, Vaibhav
Agrawal, Manali
Onasanwo, Samuel Adetunji
Madhur, Gaurav
Rastogi, Preeti
Pandey, Haushila Prasad
Palit, Gautam
Narender, Tadigoppula
Item Type: 
Journal Article
Publication Title: 
Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Journal Abbreviation: 
Phytomedicine
Publication Date: 
4/15/2013
Publication Year: 
2013
Pages: 
506-511
Volume: 
20
Issue: 
6
ISSN: 
1618-095X
DOI: 
10.1016/j.phymed.2013.01.002
Library Catalog: 
PubMed
Extra: 
PMID: 23462212

Turabian/Chicago Citation

Vaibhav Mishra, Manali Agrawal, Samuel Adetunji Onasanwo, Gaurav Madhur, Preeti Rastogi, Haushila Prasad Pandey, Gautam Palit and Tadigoppula Narender. 4/15/2013. "Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers." Phytomedicine: International Journal of Phytotherapy and Phytopharmacology 20: 6: 506-511. 10.1016/j.phymed.2013.01.002.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.phymed.2013.01.002 | issn = 1618-095X | volume = 20 | pages = 506-511 | last = Mishra | first = Vaibhav | coauthors = Agrawal, Manali, Onasanwo, Samuel Adetunji, Madhur, Gaurav, Rastogi, Preeti, Pandey, Haushila Prasad, Palit, Gautam, Narender, Tadigoppula | title = Anti-secretory and cyto-protective effects of chebulinic acid isolated from the fruits of Terminalia chebula on gastric ulcers | journal = Phytomedicine: International Journal of Phytotherapy and Phytopharmacology | date = 4/15/2013 | pmid = | pmc = }} </ref>