Antimutagenic activity of Terminalia chebula (myroblan) in Salmonella typhimurium
Language: 
English
Abstract: 

Antimutagenicity of water and chloroform extracts of dried myroblan Terminalia chebula was determined against two direct acting mutagens, sodium azide and 4-nitro-o-phenylenediamine (NPD) in strains TA100 and TA1535, and TA97a and TA98 of Salmonella typhimurium respectively and S9-dependent mutagen 2-aminofluorene (2-AF) in TA97a, TA98 and TA100 strains. Water extract reduced NPD as well as 2-AF induced his+ revertants significantly but did not have any perceptible effect against sodium azide included his+ revertants in TA100 and TA1535 strains of S. typhimurium. The pre-incubation studies, where the extract was incubated at 37 degrees C for 30 min with the said mutagen prior to plating, enhanced the inhibitory effect. Autoclaving the water extract reduced the inhibitory effect but the reduction in the effect was not significant. No inhibitory effect was observed in any of the strains and against any of the test mutagens with chloroform extract.

Author(s): 
Grover, I. S.
Bala, S.
Item Type: 
Journal Article
Publication Title: 
Indian Journal of Experimental Biology
Journal Abbreviation: 
Indian J. Exp. Biol.
Publication Date: 
1992-04
Publication Year: 
1992
Pages: 
339-341
Volume: 
30
Issue: 
4
ISSN: 
0019-5189
Library Catalog: 
PubMed
Extra: 
PMID: 1459604

Turabian/Chicago Citation

I. S. Grover and S. Bala. 1992-04. "Antimutagenic activity of Terminalia chebula (myroblan) in Salmonella typhimurium." Indian Journal of Experimental Biology 30: 4: 339-341.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0019-5189 | volume = 30 | pages = 339-341 | last = Grover | first = I. S. | coauthors = Bala, S. | title = Antimutagenic activity of Terminalia chebula (myroblan) in Salmonella typhimurium | journal = Indian Journal of Experimental Biology | date = 1992-04 | pmid = | pmc = }} </ref>