Antimycobacterial activity of two natural alkaloids, vasicine acetate and 2-acetyl benzylamine, isolated from Indian shrub Adhatoda vasica Ness. leaves
Language: 
English
Abstract: 

In folk medicine, Adhatoda vasica Ness. (Acanthaceae) is used to treat asthma and cough. The leaves of A. vasica were powdered and extracted with hexane, ethyl acetate and methanol. The hexane extract showed 97 percent reduction in colony-forming units (CFU) at 100 microg/ml. The hexane extract was subjected to column chromatography. Two natural compounds, vasicine acetate and 2-acetyl benzylamine, were isolated from it. They were bioassayed against Mycobacterium tuberculosis. The two compounds showed strong antimycobacterial activity. Vasicine acetate and 2-acetyl benzylamine isolated from hexane extract of A. vasica leaves, significantly inhibited M. tuberculosis and one multi-drug-resistant (MDR) strain and one sensitive strain at 200 and 50 microg/ml, respectively. Our study demonstrated that both the compounds, vasicine acetate and 2-acetyl benzylamine, could be evaluated further for developing a drug to control M. tuberculosis.

Author(s): 
Ignacimuthu, S.
Shanmugam, N.
Item Type: 
Journal Article
Publication Title: 
Journal of Biosciences
Journal Abbreviation: 
J. Biosci.
Publication Date: 
Dec 2010
Publication Year: 
2010
Pages: 
565-570
Volume: 
35
Issue: 
4
ISSN: 
0973-7138
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 21289439

Turabian/Chicago Citation

S. Ignacimuthu and N. Shanmugam. Dec 2010. "Antimycobacterial activity of two natural alkaloids, vasicine acetate and 2-acetyl benzylamine, isolated from Indian shrub Adhatoda vasica Ness. leaves." Journal of Biosciences 35: 4: 565-570.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0973-7138 | volume = 35 | pages = 565-570 | last = Ignacimuthu | first = S. | coauthors = Shanmugam, N. | title = Antimycobacterial activity of two natural alkaloids, vasicine acetate and 2-acetyl benzylamine, isolated from Indian shrub Adhatoda vasica Ness. leaves | journal = Journal of Biosciences | date = Dec 2010 | pmid = | pmc = }} </ref>