Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal
Language: 
English
Short Title: 
Antioxidant Supplements and Gastrointestinal Diseases
Abstract: 

The gastrointestinal tract digests and absorbs dietary nutrients, protects the body against physical and chemical damage from contents in its lumen, provides immunity against external antigens, and keeps an optimum environment for the gut microbiota. These functions cannot be performed normally in several diseases of which the following are discussed here: irritable bowel syndrome and inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. Because these diseases are associated with oxidative stress, a host of antioxidant supplements are used for maintenance and recovery of the gut functions. However, the benefits of these supplements have not been established. The available 80 human trials were rated for levels of confidence and for benefits of the antioxidant supplements. For Crohn's disease, the supplements for which clear benefits occurred in at least 2 studies were allopurinol, Boswellia serrata (frankincense or shallaki), Artemesia species (wormwood), Tripterygium wilfordii (léi g?ng téng), and omega-3 fatty acids. Similar beneficial supplements for ulcerative colitis were allopurinol, Matricaria chamomilla (chamomile), Curcuma longa (curcumin in turmeric), and omega-3 fatty acids. There was also a clear benefit for ulcerative colitis in 2 studies where a multiherbal Chinese medicine preparation and an Ayurvedic medicine preparation were used. For irritable bowel syndrome, there was only a marginal benefit of some of the antioxidant supplements. Thus, some antioxidant supplements may be beneficial at certain stages of specific diseases. This is consistent with the current concept that antioxidants act by inhibiting oxidative stress pathways in a tissue- and environment-specific manner and not by simply acting as scavengers.

Author(s): 
Khan, Islam
Samson, Sue E.
Grover, Ashok Kumar
Item Type: 
Journal Article
Publication Title: 
Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Journal Abbreviation: 
Med Princ Pract
Publication Date: 
2017
Publication Year: 
2017
Pages: 
201-217
Volume: 
26
Issue: 
3
ISSN: 
1423-0151
DOI: 
10.1159/000468988
Library Catalog: 
PubMed
Extra: 
PMID: 28278495

Turabian/Chicago Citation

Islam Khan, Sue E. Samson and Ashok Kumar Grover. 2017. "Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal." Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre 26: 3: 201-217. 10.1159/000468988.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1159/000468988 | issn = 1423-0151 | volume = 26 | pages = 201-217 | last = Khan | first = Islam | coauthors = Samson, Sue E., Grover, Ashok Kumar | title = Antioxidant Supplements and Gastrointestinal Diseases: A Critical Appraisal | journal = Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre | date = 2017 | pmid = | pmc = }} </ref>