Antitumor effect of stilbenoids from Vateria indica against allografted sarcoma S-180 in animal model
Language: 
English
Abstract: 

Dipterocarpaceous plants contain various resveratrol oligomers that exhibit a variety of biological activities, such as antibacterial and antitumor effects. Previously, we found that vaticanol C, a resveratrol tetramer, exhibits strong cytotoxicity against various tumor cell lines. In the present study, we examined the antitumor activity of the ethanol extract from the stem bark of Vateria indica, which has been traditionally used for health and healing diseases as Ayurveda in India. High-performance liquid chromatography analysis showed that the extract contains bergenin, hopeaphenol, vaticanol B, vaticanol C, and epsilon-viniferin. The in vitro assay displayed the extract's anti-cancer activity against mouse sarcoma 180 cells (IC50=29.5 microM). In the animal study, the tumor growth of sarcoma S-180 cells subcutaneously allografted in DDY mice was significantly retarded by oral administration of the extract (30 or 100 mg/kg body weight: P < 0.001). The extract did not show significant toxicity to mice even at a dosage of 1000 mg/kg body weight by daily oral administration for 28 days. These results demonstrated that the ethanol extract containing various stilbenoids from the stem bark of V. indica has the potent antitumor activity.

Author(s): 
Mishima, Satoshi
Matsumoto, Kenji
Futamura, Yoshihiro
Araki, Yoko
Ito, Tetsuro
Tanaka, Toshiyuki
Iinuma, Munekazu
Nozawa, Yoshinori
Akao, Yukihiro
Item Type: 
Journal Article
Publication Title: 
Journal of Experimental Therapeutics & Oncology
Journal Abbreviation: 
J. Exp. Ther. Oncol.
Publication Date: 
2003 Sep-Oct
Publication Year: 
2003
Pages: 
283-288
Volume: 
3
Issue: 
5
ISSN: 
1359-4117
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 14696625

Turabian/Chicago Citation

Satoshi Mishima, Kenji Matsumoto, Yoshihiro Futamura, Yoko Araki, Tetsuro Ito, Toshiyuki Tanaka, Munekazu Iinuma, Yoshinori Nozawa and Yukihiro Akao. 2003 Sep-Oct. "Antitumor effect of stilbenoids from Vateria indica against allografted sarcoma S-180 in animal model." Journal of Experimental Therapeutics & Oncology 3: 5: 283-288.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1359-4117 | volume = 3 | pages = 283-288 | last = Mishima | first = Satoshi | coauthors = Matsumoto, Kenji, Futamura, Yoshihiro, Araki, Yoko, Ito, Tetsuro, Tanaka, Toshiyuki, Iinuma, Munekazu, Nozawa, Yoshinori, Akao, Yukihiro | title = Antitumor effect of stilbenoids from Vateria indica against allografted sarcoma S-180 in animal model | journal = Journal of Experimental Therapeutics & Oncology | date = 2003 Sep-Oct | pmid = | pmc = }} </ref>