Artemisinin attenuates post-infarct myocardial remodeling by down-regulating the NF-?B pathway
Language: 
English
Abstract: 

Myocardial infarction (MI) leads to progressive left ventricular (LV) dilatation and is associated with interstitial fibrosis in the non-infarcted myocardium. The NF-?B signaling pathway plays an important role in ventricular remodeling after MI. Recent studies have indicated that the anti-malarial agent artemisinin can inhibit NF-?B activation, which may attenuate post-infarct myocardial remodeling. In this study, we investigated the effect of artemisinin on post-infarct myocardial remodeling using a rat model of MI. Adult male Sprague Dawley rats were divided into a sham group (n = 10) and MI groups that were treated either with oral gavage of artemisinin (75 mg/kg/day, n = 20) or vehicle (0.5% carboxymethyl cellulose, n = 20) three times a day for 4 weeks. Each treatment was started at 24 hours after ligation of the left anterior descending coronary artery. Four weeks after MI, the artemisinin-treated group showed a significantly improved survival rate compared with that of the vehicle-treated group (65% vs. 40%, P < 0.05). Although infarct size was similar in both groups, echocardiography showed significant improvements in cardiac function and left ventricular dimensions in the artemisinin-treated group. Moreover, the degree of myocardial fibrosis and elevated levels of fibrosis-related factors [transforming growth factor-?1, collagen type I, matrix metalloproteinase (MMP)-2 and MMP-9] in the non-infarcted myocardium were remarkably ameliorated by artemisinin (all P < 0.05). Importantly, artemisinin inhibited the NF-?B pathway by blocking IKB? phosphorylation. In conclusion, artemisinin may attenuate post-infarct myocardial remodeling by down-regulating the NF-?B pathway.

Author(s): 
Gu, Yongwei
Wang, Xi
Wang, Xin
Yuan, Mingjie
Wu, Gang
Hu, Juan
Tang, Yanhong
Huang, Congxin
Item Type: 
Journal Article
Publication Title: 
The Tohoku Journal of Experimental Medicine
Journal Abbreviation: 
Tohoku J. Exp. Med.
Publication Date: 
2012
Publication Year: 
2012
Pages: 
161-170
Volume: 
227
Issue: 
3
ISSN: 
1349-3329
Library Catalog: 
PubMed
Extra: 
PMID: 22729178

Turabian/Chicago Citation

Yongwei Gu, Xi Wang, Xin Wang, Mingjie Yuan, Gang Wu, Juan Hu, Yanhong Tang and Congxin Huang. 2012. "Artemisinin attenuates post-infarct myocardial remodeling by down-regulating the NF-?B pathway." The Tohoku Journal of Experimental Medicine 227: 3: 161-170.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1349-3329 | volume = 227 | pages = 161-170 | last = Gu | first = Yongwei | coauthors = Wang, Xi, Wang, Xin, Yuan, Mingjie, Wu, Gang, Hu, Juan, Tang, Yanhong, Huang, Congxin | title = Artemisinin attenuates post-infarct myocardial remodeling by down-regulating the NF-?B pathway | journal = The Tohoku Journal of Experimental Medicine | date = 2012 | pmid = | pmc = }} </ref>