Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation
Language: 
English
Abstract: 

Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemisinin, as well as parthenolide, inhibits nitric oxide synthesis in cytokine-stimulated human astrocytoma T67 cells. These results suggest that artemisinin, in addition to its antiparasitic properties, could also exert a therapeutic effect on neurological complications of malaria.

Author(s): 
Aldieri, Elisabetta
Atragene, Daniela
Bergandi, Loredana
Riganti, Chiara
Costamagna, Costanzo
Bosia, Amalia
Ghigo, Dario
Item Type: 
Journal Article
Publication Title: 
FEBS letters
Journal Abbreviation: 
FEBS Lett.
Publication Date: 
9/25/2003
Publication Year: 
2003
Pages: 
141-144
Volume: 
552
Issue: 
2/3/2015
ISSN: 
0014-5793
Library Catalog: 
PubMed
Extra: 
PMID: 14527676

Turabian/Chicago Citation

Elisabetta Aldieri, Daniela Atragene, Loredana Bergandi, Chiara Riganti, Costanzo Costamagna, Amalia Bosia and Dario Ghigo. 9/25/2003. "Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation." FEBS letters 552: 2/3/2015: 141-144.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0014-5793 | volume = 552 | pages = 141-144 | last = Aldieri | first = Elisabetta | coauthors = Atragene, Daniela, Bergandi, Loredana, Riganti, Chiara, Costamagna, Costanzo, Bosia, Amalia, Ghigo, Dario | title = Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation | journal = FEBS letters | date = 9/25/2003 | pmid = | pmc = }} </ref>