Arthroplasty for ochronotic arthritis: no failure of 11 replacements in 3 patients followed 6-12 years
Language: 
English
Short Title: 
Arthroplasty for ochronotic arthritis
Abstract: 

BACKGROUND: Alkaptonuria is a rare single-gene disorder characterized by black pigmentation of cartilage and other connective tissues. Premature degenerative arthritis affects the large joints in many of these of patients. Medical treatment is limited to a protein-restricted diet (phenylalanine and tyrosine) with surgery reserved for end-stage joint disease. As in other metabolic bone diseases, there are concerns about the quality and strength of affected bones and therefore the suitability and longevity of replacement arthroplasty. The histopathology and outcome of joint replacement for alkaptonuric arthritis is unknown and limited to sporadic case reports. PATIENTS AND RESULTS: We describe 11 joint replacements in 3 patients with alkaptonuric polyarthropathy, including shoulder and elbow replacements not previously reported. No prosthetic failures occurred in up to 12 years of follow-up. INTERPRETATION: Total joint replacement is an acceptable treatment for degenerative joint disease in alkaptonuric patients, with implant survival comparable to that found in patients with osteoarthritis.

Author(s): 
Spencer, Jonathan M. F.
Gibbons, C. L. Maxime H.
Sharp, Robert J.
Carr, Andrew J.
Athanasou, Nicholas A.
Item Type: 
Journal Article
Publication Title: 
Acta Orthopaedica Scandinavica
Journal Abbreviation: 
Acta Orthop Scand
Publication Date: 
2004-06
Publication Year: 
2004
Pages: 
355-358
Volume: 
75
Issue: 
3
ISSN: 
0001-6470
DOI: 
10.1080/00016470410001321
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 15260431

Turabian/Chicago Citation

Jonathan M. F. Spencer, C. L. Maxime H. Gibbons, Robert J. Sharp, Andrew J. Carr and Nicholas A. Athanasou. 2004-06. "Arthroplasty for ochronotic arthritis: no failure of 11 replacements in 3 patients followed 6-12 years." Acta Orthopaedica Scandinavica 75: 3: 355-358. 10.1080/00016470410001321.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1080/00016470410001321 | issn = 0001-6470 | volume = 75 | pages = 355-358 | last = Spencer | first = Jonathan M. F. | coauthors = Gibbons, C. L. Maxime H., Sharp, Robert J., Carr, Andrew J., Athanasou, Nicholas A. | title = Arthroplasty for ochronotic arthritis: no failure of 11 replacements in 3 patients followed 6-12 years | journal = Acta Orthopaedica Scandinavica | date = 2004-06 | pmid = | pmc = }} </ref>