Association of the K153R polymorphism in the myostatin gene and extreme longevity

The myostatin (MSTN) gene is a candidate to influence extreme longevity owing to its role in modulating muscle mass and sarcopenia and especially in inhibiting the main nutrient-sensing pathway involved in longevity, i.e. mammalian target of rapamycin. We compared allele/genotype distributions of the exonic MSTN variants K153R (rs1805086), E164K (rs35781413), I225T and P198A, in Spanish centenarians (cases, n = 156; 132 women, age range 100-111 years) and younger adults (controls, n = 384; 167 women, age <50 years). No subject of either group carried a mutant allele of the E164K, I225T or P198A variation. The frequency of the variant R allele was significantly higher in centenarians (7.1%) than in controls (2.7%) (P = 0.001). The odds ratio of being a centenarian if the subject had the R allele was 3.48 (95% confidence interval 1.67-7.28, P = 0.001), compared to the control group, after adjusting for sex. The results were replicated in an Italian cohort (centenarians, n = 79 (40 women), age range 100-104 years; younger controls, n = 316 (155 women), age <50 years), where a higher frequency of the R allele in centenarians (7.6%) compared to controls (3.0%) (P = 0.004) was independently confirmed. Although more research is needed, the variant allele of the MSTN K153R polymorphism could be among the genetic contributors associated with exceptional longevity.

Garatachea, Nuria
PinÛs, Tom‡s
C·mara, Yolanda
RodrÌguez-Romo, Gabriel
Emanuele, Enzo
Ricevuti, Giovanni
Venturini, Letizia
Santos-Lozano, Alejandro
Santiago-Dorrego, Catalina
Fiuza-Luces, Carmen
Yvert, Thomas
Andreu, Antoni L.
Lucia, Alejandro
Item Type: 
Journal Article
Publication Title: 
Age (Dordrecht, Netherlands)
Journal Abbreviation: 
Age (Dordr)
Publication Date: 
Publication Year: 
Library Catalog: 
NCBI Published Medical (?)
PMID: 23354683 PMCID: PMC3825013

Turabian/Chicago Citation

Nuria Garatachea, Tom‡s PinÛs, Yolanda C·mara, Gabriel RodrÌguez-Romo, Enzo Emanuele, Giovanni Ricevuti, Letizia Venturini, Alejandro Santos-Lozano, Catalina Santiago-Dorrego, Carmen Fiuza-Luces, Thomas Yvert, Antoni L. Andreu and Alejandro Lucia. 2013-12. "Association of the K153R polymorphism in the myostatin gene and extreme longevity." Age (Dordrecht, Netherlands) 35: 6: 2445-2454. 10.1007/s11357-013-9513-3.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s11357-013-9513-3 | issn = 1574-4647 | volume = 35 | pages = 2445-2454 | last = Garatachea | first = Nuria | coauthors = PinÛs, Tom‡s, C·mara, Yolanda, RodrÌguez-Romo, Gabriel, Emanuele, Enzo, Ricevuti, Giovanni, Venturini, Letizia, Santos-Lozano, Alejandro, Santiago-Dorrego, Catalina, Fiuza-Luces, Carmen, Yvert, Thomas, Andreu, Antoni L., Lucia, Alejandro | title = Association of the K153R polymorphism in the myostatin gene and extreme longevity | journal = Age (Dordrecht, Netherlands) | date = 2013-12 | pmid = | pmc = }} </ref>