Association of the K153R polymorphism in the myostatin gene and extreme longevity
Language: 
English
Abstract: 

The myostatin (MSTN) gene is a candidate to influence extreme longevity owing to its role in modulating muscle mass and sarcopenia and especially in inhibiting the main nutrient-sensing pathway involved in longevity, i.e. mammalian target of rapamycin. We compared allele/genotype distributions of the exonic MSTN variants K153R (rs1805086), E164K (rs35781413), I225T and P198A, in Spanish centenarians (cases, n = 156; 132 women, age range 100-111 years) and younger adults (controls, n = 384; 167 women, age <50 years). No subject of either group carried a mutant allele of the E164K, I225T or P198A variation. The frequency of the variant R allele was significantly higher in centenarians (7.1%) than in controls (2.7%) (P = 0.001). The odds ratio of being a centenarian if the subject had the R allele was 3.48 (95% confidence interval 1.67-7.28, P = 0.001), compared to the control group, after adjusting for sex. The results were replicated in an Italian cohort (centenarians, n = 79 (40 women), age range 100-104 years; younger controls, n = 316 (155 women), age <50 years), where a higher frequency of the R allele in centenarians (7.6%) compared to controls (3.0%) (P = 0.004) was independently confirmed. Although more research is needed, the variant allele of the MSTN K153R polymorphism could be among the genetic contributors associated with exceptional longevity.

Author(s): 
Garatachea, Nuria
PinÛs, Tom‡s
C·mara, Yolanda
RodrÌguez-Romo, Gabriel
Emanuele, Enzo
Ricevuti, Giovanni
Venturini, Letizia
Santos-Lozano, Alejandro
Santiago-Dorrego, Catalina
Fiuza-Luces, Carmen
Yvert, Thomas
Andreu, Antoni L.
Lucia, Alejandro
Item Type: 
Journal Article
Publication Title: 
Age (Dordrecht, Netherlands)
Journal Abbreviation: 
Age (Dordr)
Publication Date: 
2013-12
Publication Year: 
2013
Pages: 
2445-2454
Volume: 
35
Issue: 
6
ISSN: 
1574-4647
DOI: 
10.1007/s11357-013-9513-3
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23354683 PMCID: PMC3825013

Turabian/Chicago Citation

Nuria Garatachea, Tom‡s PinÛs, Yolanda C·mara, Gabriel RodrÌguez-Romo, Enzo Emanuele, Giovanni Ricevuti, Letizia Venturini, Alejandro Santos-Lozano, Catalina Santiago-Dorrego, Carmen Fiuza-Luces, Thomas Yvert, Antoni L. Andreu and Alejandro Lucia. 2013-12. "Association of the K153R polymorphism in the myostatin gene and extreme longevity." Age (Dordrecht, Netherlands) 35: 6: 2445-2454. 10.1007/s11357-013-9513-3.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s11357-013-9513-3 | issn = 1574-4647 | volume = 35 | pages = 2445-2454 | last = Garatachea | first = Nuria | coauthors = PinÛs, Tom‡s, C·mara, Yolanda, RodrÌguez-Romo, Gabriel, Emanuele, Enzo, Ricevuti, Giovanni, Venturini, Letizia, Santos-Lozano, Alejandro, Santiago-Dorrego, Catalina, Fiuza-Luces, Carmen, Yvert, Thomas, Andreu, Antoni L., Lucia, Alejandro | title = Association of the K153R polymorphism in the myostatin gene and extreme longevity | journal = Age (Dordrecht, Netherlands) | date = 2013-12 | pmid = | pmc = }} </ref>