Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain

Bacopa monniera is a perennial herb, and is used as a nerve tonic in äyurveda, a traditional medicinal system in India. Aluminium-induced neurotoxicity is well known and different salts of aluminium have been reported to accelerate oxidative damage to biomolecules like lipids, proteins and nucleic acids. The objective of the present study was to investigate whether Bacopa monniera could potentially inhibit aluminium toxicity in the cerebral cortex. Male Wister rats (8 months old) were administered with AlCl(3) orally at a dose of 50mg/kg/day in drinking water for 1 month. Experimental rats were given AlCl(3) along with Bacopa monniera extract at a dose of 40 mg/kg/day. One group of rats was treated with l-deprenyl at a dose of 1mg/kg/day along with AlCl(3) treatment. We have observed that Bacopa monniera prevented accumulation of lipid and protein damage significantly, which resulted from aluminium intake. Decline in the activity of endogenous antioxidant enzymes associated with aluminium administration was also inhibited by Bacopa monniera extract. The potential of Bacopa monniera to inhibit Al-induced oxidative stress was observed to be similar to that of l-deprenyl, which was taken as standard. The potential of Bacopa monniera extract to prevent aluminium neurotoxicity was reflected at the microscopic level as well, indicative of its neuroprotective effects. These findings strongly implicate that Bacopa monniera has potential to protect brain from oxidative damage resulting from aluminium toxicity.

Jyoti, Amar
Sethi, Pallavi
Sharma, Deepak
Item Type: 
Journal Article
Publication Title: 
Journal of Ethnopharmacology
Journal Abbreviation: 
J Ethnopharmacol
Publication Date: 
Apr 20, 2007
Publication Year: 
Library Catalog: 
NCBI Published Medical (?)
PMID: 17189676

Turabian/Chicago Citation

Amar Jyoti, Pallavi Sethi and Deepak Sharma. Apr 20, 2007. "Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain." Journal of Ethnopharmacology 111: 1: 56-62. 10.1016/j.jep.2006.10.037.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.jep.2006.10.037 | issn = 0378-8741 | volume = 111 | pages = 56-62 | last = Jyoti | first = Amar | coauthors = Sethi, Pallavi, Sharma, Deepak | title = Bacopa monniera prevents from aluminium neurotoxicity in the cerebral cortex of rat brain | journal = Journal of Ethnopharmacology | date = Apr 20, 2007 | pmid = | pmc = }} </ref>