Bile acids, chaperones, and mammalian longevity
Language: 
English
Abstract: 

Bile acids are detergent molecules derived from cholesterol in the liver that are important for the metabolism and absorption of lipids in the intestine. Bile acids are also steroid hormones activating specific nuclear receptors and G protein-coupled receptors. Conjugated bile acids are cytoprotective and anticarcinogenic. Bile acid synthesis and bile flow decreases markedly during aging. The housekeeping molecular chaperones are stress response proteins, important for the processes of folding, maintenance, and repair of proteins, RNA, and DNA, as well as for the structure and function of the steroid hormone receptors. The level of expression of the molecular chaperones correlates with mammalian longevity as well as with the life span of differentiated cells. The functions of the chaperone machinery are progressively impaired during aging, and the progressive age-related impairment of these housekeeping mechanisms probably contributes to the phenotype of aging. This review presents evidence that the bile acids are chemical chaperones, improving the general chaperone defense, and thus serve to support an epigenetic mechanism of possible significance for the evolution of mammalian longevity, as well as for the attainment of healthy aging.

Author(s): 
Kr¯ll, Jens
Item Type: 
Journal Article
Publication Title: 
Rejuvenation Research
Journal Abbreviation: 
Rejuvenation Res
Publication Date: 
2012-04
Publication Year: 
2012
Pages: 
210-212
Volume: 
15
Issue: 
2
ISSN: 
1557-8577
DOI: 
10.1089/rej.2011.1286
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22533434

Turabian/Chicago Citation

Jens Kr¯ll. 2012-04. "Bile acids, chaperones, and mammalian longevity." Rejuvenation Research 15: 2: 210-212. 10.1089/rej.2011.1286.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1089/rej.2011.1286 | issn = 1557-8577 | volume = 15 | pages = 210-212 | last = Kr¯ll | first = Jens | coauthors = | title = Bile acids, chaperones, and mammalian longevity | journal = Rejuvenation Research | date = 2012-04 | pmid = | pmc = }} </ref>