Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae)
Language: 
English
Abstract: 

The aqueous extract of galls from Terminalia chebula Retz. (Combretaceae) was fractionated on Diaion and refractionated on octadecyl silica column. Six phenolic compounds were isolated and identified as gallic acid (1), punicalagin (2), isoterchebulin (3), 1,3,6-tri-O-galloyl-?-D-glucopyranose (4), chebulagic acid (5) and chebulinic acid (6). All of the compounds showed stronger 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and melanin inhibitory activities than ascorbic acid, butylated hydroxytoluene, ?-tocopherol, arbutin and kojic acid, the reference compounds. Gallic acid (1) exhibited inhibitory activity against nitric oxide production in lipopolysaccharide-activated macrophages. However, all isolated compounds exhibited less activity than the reference compounds in mushroom tyrosinase inhibition and human tumour cytotoxicity assays. This study has demonstrated that the phenolic compounds isolated from galls of T. chebula might contribute significantly due to their antioxidant and whitening activities.

Author(s): 
Manosroi, Aranya
Jantrawut, Pensak
Akazawa, Hiroyuki
Akihisa, Toshihiro
Manosroi, Jiradej
Item Type: 
Journal Article
Publication Title: 
Natural Product Research
Journal Abbreviation: 
Nat. Prod. Res.
Publication Date: 
2010-12
Publication Year: 
2010
Pages: 
1915-1926
Volume: 
24
Issue: 
20
ISSN: 
1478-6427
DOI: 
10.1080/14786419.2010.488631
Library Catalog: 
PubMed
Extra: 
PMID: 21108118

Turabian/Chicago Citation

Aranya Manosroi, Pensak Jantrawut, Hiroyuki Akazawa, Toshihiro Akihisa and Jiradej Manosroi. 2010-12. "Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae)." Natural Product Research 24: 20: 1915-1926. 10.1080/14786419.2010.488631.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1080/14786419.2010.488631 | issn = 1478-6427 | volume = 24 | pages = 1915-1926 | last = Manosroi | first = Aranya | coauthors = Jantrawut, Pensak, Akazawa, Hiroyuki, Akihisa, Toshihiro, Manosroi, Jiradej | title = Biological activities of phenolic compounds isolated from galls of Terminalia chebula Retz. (Combretaceae) | journal = Natural Product Research | date = 2010-12 | pmid = | pmc = }} </ref>