Brain Derived Neurotrophic Factor: epigenetic regulation in psychiatric disorders
Language: 
English
Short Title: 
Brain Derived Neurotrophic Factor
Abstract: 

Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. Indeed, BDNF therapies are currently being investigated in animal models and clinical studies. However, very little is currently known about the mechanisms that deregulate BDNF gene expression in these disorders. The BDNF gene structure and tissue expression pattern is complex, controlled in humans by 9 different gene promoters. Recently, epigenetic changes at the BDNF gene locus have been proposed to provide a link between gene and environment. In this review, we will summarize the current knowledge of BDNF epigenetic regulation with respect to psychiatric disorders and describe how this information can be applied in therapy and future research.

Author(s): 
Mitchelmore, Cathy
Gede, Lene
Item Type: 
Journal Article
Publication Title: 
Brain Research
Journal Abbreviation: 
Brain Res.
Publication Date: 
10/24/2014
Publication Year: 
2014
Pages: 
162-172
Volume: 
1586
ISSN: 
1872-6240
DOI: 
10.1016/j.brainres.2014.06.037
Library Catalog: 
PubMed
Extra: 
PMID: 25223903

Turabian/Chicago Citation

Cathy Mitchelmore and Lene Gede. 10/24/2014. "Brain Derived Neurotrophic Factor: epigenetic regulation in psychiatric disorders." Brain Research 1586: 162-172. 10.1016/j.brainres.2014.06.037.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.brainres.2014.06.037 | issn = 1872-6240 | volume = 1586 | pages = 162-172 | last = Mitchelmore | first = Cathy | coauthors = Gede, Lene | title = Brain Derived Neurotrophic Factor: epigenetic regulation in psychiatric disorders | journal = Brain Research | date = 10/24/2014 | pmid = | pmc = }} </ref>