Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease
Language: 
English
Abstract: 

OBJECTIVE: Bromelain, a clinically used pineapple extract and natural product, has reported anti-inflammatory and immunomodulatory activities. The purpose of this study was to determine the effect of bromelain treatment in an ovalbumin (OVA)-induced murine model of allergic airway disease (AAD). METHODS: To establish AAD, mice were sensitized with intraperitoneal (i.p.) OVA/alum and challenged with daily OVA aerosols. Mice were treated i.p. with either saline, 2 or 6 mg/kg bromelain, twice daily for four consecutive days. Bronchoalveolar lavage leukocytes and cytokines, lung histology, airway hyperresponsiveness, and lymphocyte populations via flow cytometry were compared between groups. RESULTS: Bromelain treatment of AAD mice resulted in reduced total BAL leukocytes, eosinophils, CD4+ and CD8+ T lymphocytes, CD4+/CD8+ T cell ratio, and IL-13. CONCLUSION: Bromelain attenuated development of AAD while altering CD4+ to CD8+ T lymphocyte populations. The reduction in AAD outcomes suggests that bromelain may have similar effects in the treatment of human asthma and hypersensitivity disorders.

Author(s): 
Secor, Eric R.
Carson, William F.
Cloutier, Michelle M.
Guernsey, Linda A.
Schramm, Craig M.
Wu, Carol A.
Thrall, Roger S.
Item Type: 
Journal Article
Publication Title: 
Cellular Immunology
Journal Abbreviation: 
Cell. Immunol.
Publication Date: 
Sep 2005
Publication Year: 
2005
Pages: 
68-75
Volume: 
237
Issue: 
1
ISSN: 
0008-8749
DOI: 
10.1016/j.cellimm.2005.10.002
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 16337164 PMCID: PMC2576519

Turabian/Chicago Citation

Eric R. Secor, William F. Carson, Michelle M. Cloutier, Linda A. Guernsey, Craig M. Schramm, Carol A. Wu and Roger S. Thrall. Sep 2005. "Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease." Cellular Immunology 237: 1: 68-75. 10.1016/j.cellimm.2005.10.002.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.cellimm.2005.10.002 | issn = 0008-8749 | volume = 237 | pages = 68-75 | last = Secor | first = Eric R. | coauthors = Carson, William F., Cloutier, Michelle M., Guernsey, Linda A., Schramm, Craig M., Wu, Carol A., Thrall, Roger S. | title = Bromelain exerts anti-inflammatory effects in an ovalbumin-induced murine model of allergic airway disease | journal = Cellular Immunology | date = Sep 2005 | pmid = | pmc = }} </ref>