Calcium channels are involved in the hypnotic-anesthetic action of dexmedetomidine in rats
Language: 
English
Abstract: 

Our study examined whether calcium channels are involved in the anesthetic action of dexmedetomidine (100-300 micrograms/kg), a highly selective alpha 2-adrenoceptor agonist. To investigate this, we studied the effects of verapamil (1.25 or 2.5 mg/kg), a calcium channel blocker, and BAY K8644 (0.5 or 1 mg/kg), a calcium channel agonist, on the hypnotic-anesthetic effect of dexmedetomidine in rats. Loss of the righting reflex was used to determine the presence of anesthesia, and its length in minutes was referred to as the duration of hypnosis. Verapamil significantly enhanced the duration of the hypnotic-anesthetic action of dexmedetomidine (P less than 0.05). In contrast, BAY K8644 caused a significantly increased onset of hypnosis (P less than 0.001) and attenuated the anesthetic property of dexmedetomidine. These results suggest that the hypnotic-anesthetic action of dexmedetomidine is influenced by the activation/gating of calcium channels.

Author(s): 
Horvàth, G.
Szikszay, M.
Benedek, G.
Item Type: 
Journal Article
Publication Title: 
Anesthesia and Analgesia
Journal Abbreviation: 
Anesth. Analg.
Publication Date: 
Jun-92
Publication Year: 
1992
Pages: 
884-888
Volume: 
74
Issue: 
6
ISSN: 
0003-2999
Library Catalog: 
PubMed
Extra: 
PMID: 1375817

Turabian/Chicago Citation

G. Horvàth, M. Szikszay and G. Benedek. Jun-92. "Calcium channels are involved in the hypnotic-anesthetic action of dexmedetomidine in rats." Anesthesia and Analgesia 74: 6: 884-888.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0003-2999 | volume = 74 | pages = 884-888 | last = Horvàth | first = G. | coauthors = Szikszay, M., Benedek, G. | title = Calcium channels are involved in the hypnotic-anesthetic action of dexmedetomidine in rats | journal = Anesthesia and Analgesia | date = Jun-92 | pmid = | pmc = }} </ref>