Calorie restriction and bone health in young, overweight individuals
Language: 
English
Abstract: 

BACKGROUND: Calorie restriction (CR) is promoted to increase longevity, yet this regimen could lead to bone loss and fracture and therefore affect quality of life. METHODS: Forty-six individuals were randomized to 4 groups for 6 months: (1) healthy diet (control group); (2) 25% CR from baseline energy requirements (CR group); (3) 25% energy deficit by a combination of CR and increased aerobic exercise (CR + EX group); and (4) low-calorie diet (890 kcal/d; goal, 15% weight loss) followed by weight maintenance (LCD group). Bone mineral density (total body and hip by dual-energy x-ray absorptiometry) and serum bone markers (bone-specific alkaline phosphatase, osteocalcin, cross-linked C-telopeptide of type I collagen, and cross-linked N-telopeptide of type I collagen) were measured at baseline and after 6 months. RESULTS: Mean +/- SE body weight was reduced by -1.0% +/- 1.1% (control), -10.4% +/- 0.9% (CR), -10.0% +/- 0.8% (CR + EX), and -13.9% +/- 0.7% (LCD). Compared with the control group, none of the groups showed any change in bone mineral density for total body or hip. Bone resorption by serum cross-linked C-telopeptide of type I collagen was increased in all 3 intervention groups, with the largest change observed in the LCD group (CR, 23% +/- 10%; CR + EX, 22% +/- 9%; and LCD, 74% +/- 16% vs control, 4% +/- 10%). Serum levels of cross-linked N-telopeptide of type I collagen were also increased in the LCD group. With regard to bone formation, bone alkaline phosphatase levels were decreased in the CR group (-23% +/- 10%) but were unchanged in the CR + EX, LCD, and control groups. CONCLUSIONS: Moderate CR, with or without exercise, that preserves calcium intake for 6 months leads to large changes in body composition without significant bone loss in young adults. Longer studies with assessments of bone architecture are needed to confirm that CR nutrient-dense diets have no deleterious effect on bone health. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00099151.

Author(s): 
Redman, Leanne M.
Rood, Jennifer
Anton, Stephen D.
Champagne, Catherine
Smith, Steven R.
Ravussin, Eric
Pennington Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) Research Team
Item Type: 
Journal Article
Publication Title: 
Archives of Internal Medicine
Journal Abbreviation: 
Arch. Intern. Med.
Publication Date: 
9/22/2008
Publication Year: 
2008
Pages: 
1859-1866
Volume: 
168
Issue: 
17
ISSN: 
1538-3679
DOI: 
10.1001/archinte.168.17.1859
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 18809812 PMCID: PMC2748345

Turabian/Chicago Citation

Leanne M. Redman, Jennifer Rood, Stephen D. Anton, Catherine Champagne, Steven R. Smith, Eric Ravussin and Pennington Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) Research Team. 9/22/2008. "Calorie restriction and bone health in young, overweight individuals." Archives of Internal Medicine 168: 17: 1859-1866. 10.1001/archinte.168.17.1859.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1001/archinte.168.17.1859 | issn = 1538-3679 | volume = 168 | pages = 1859-1866 | last = Redman | first = Leanne M. | coauthors = Rood, Jennifer, Anton, Stephen D., Champagne, Catherine, Smith, Steven R., Ravussin, Eric, Pennington Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) Research Team | title = Calorie restriction and bone health in young, overweight individuals | journal = Archives of Internal Medicine | date = 9/22/2008 | pmid = | pmc = }} </ref>