Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile
Language: 
English
Abstract: 

Caloric restriction (CR) and down-regulation of the insulin/IGF pathway are the most robust interventions known to increase longevity in lower organisms. However, little is known about the molecular adaptations induced by CR in humans. Here, we report that long-term CR in humans inhibits the IGF-1/insulin pathway in skeletal muscle, a key metabolic tissue. We also demonstrate that CR induces dramatic changes of the skeletal muscle transcriptional profile that resemble those of younger individuals. Finally, in both rats and humans, CR evoked similar responses in the transcriptional profiles of skeletal muscle. This common signature consisted of three key pathways typically associated with longevity: IGF-1/insulin signaling, mitochondrial biogenesis, and inflammation. Furthermore, our data identify promising pathways for therapeutic targets to combat age-related diseases and promote health in humans.

Author(s): 
Mercken, Evi M.
Crosby, Seth D.
Lamming, Dudley W.
JeBailey, Lellean
Krzysik-Walker, Susan
Villareal, Dennis T.
Capri, Miriam
Franceschi, Claudio
Zhang, Yongqing
Becker, Kevin
Sabatini, David M.
de Cabo, Rafael
Fontana, Luigi
Item Type: 
Journal Article
Publication Title: 
Aging Cell
Journal Abbreviation: 
Aging Cell
Publication Date: 
2013-08
Publication Year: 
2013
Pages: 
645-651
Volume: 
12
Issue: 
4
ISSN: 
1474-9726
DOI: 
10.1111/acel.12088
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23601134 PMCID: PMC3714316

Turabian/Chicago Citation

Evi M. Mercken, Seth D. Crosby, Dudley W. Lamming, Lellean JeBailey, Susan Krzysik-Walker, Dennis T. Villareal, Miriam Capri, Claudio Franceschi, Yongqing Zhang, Kevin Becker, David M. Sabatini, Rafael de Cabo and Luigi Fontana. 2013-08. "Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile." Aging Cell 12: 4: 645-651. 10.1111/acel.12088.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1111/acel.12088 | issn = 1474-9726 | volume = 12 | pages = 645-651 | last = Mercken | first = Evi M. | coauthors = Crosby, Seth D., Lamming, Dudley W., JeBailey, Lellean, Krzysik-Walker, Susan, Villareal, Dennis T., Capri, Miriam, Franceschi, Claudio, Zhang, Yongqing, Becker, Kevin, Sabatini, David M., de Cabo, Rafael, Fontana, Luigi | title = Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile | journal = Aging Cell | date = 2013-08 | pmid = | pmc = }} </ref>