CD4 T-cell immunotherapy for chronic viral infections and cancer
Language: 
English
Abstract: 

During chronic infections and cancer, T cells progressively lose function and become exhausted. However, effective T-cell responses are necessary to ultimately control viral infections and tumors. Hence, strategies that either restore endogenous immune responses or provide functional T cells by adoptive immunotherapy need to be explored. CD8 T cells play a prominent role in viral infections, as well as cancer, but CD4 T cells are necessary to support CD8 T-cell function. In addition, CD4 T cells exert direct effector functions, induce optimal B-cell responses and orchestrate innate immunity. Therefore, we propose that adoptive transfer strategies should exploit CD4 T cells alone or in combination with CD8 T cells, for the treatment of chronic infections and cancer. Furthermore, since adoptively transferred cells are subject to exhaustion, combining adoptive transfer therapy with immunotherapies that inhibit T-cell exhaustion should maximize the longevity and success rate of responses.

Author(s): 
Kamphorst, Alice O.
Ahmed, Rafi
Item Type: 
Journal Article
Publication Title: 
Immunotherapy
Journal Abbreviation: 
Immunotherapy
Publication Date: 
2013-09
Publication Year: 
2013
Pages: 
975-987
Volume: 
5
Issue: 
9
ISSN: 
1750-7448
DOI: 
10.2217/imt.13.91
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23998732 PMCID: PMC3864579

Turabian/Chicago Citation

Alice O. Kamphorst and Rafi Ahmed. 2013-09. "CD4 T-cell immunotherapy for chronic viral infections and cancer." Immunotherapy 5: 9: 975-987. 10.2217/imt.13.91.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.2217/imt.13.91 | issn = 1750-7448 | volume = 5 | pages = 975-987 | last = Kamphorst | first = Alice O. | coauthors = Ahmed, Rafi | title = CD4 T-cell immunotherapy for chronic viral infections and cancer | journal = Immunotherapy | date = 2013-09 | pmid = | pmc = }} </ref>