Chloroquine- and sulfadoxine-pyrimethamine-resistant Falciparum malaria in vivo - a pilot study in rural Zambia
Language: 
English
Abstract: 

BACKGROUND: Chloroquine (CQ) and Sulfadoxine-Pyrimethamine (SP) are the predominantly used antimalarials in Zambia and other parts of East Africa, but increasing resistance of P. falciparum is a major concern. METHODS: Seventy consecutive patients with uncomplicated falciparum malaria were enrolled. In 43 patients, no prior CQ use could be demonstrated by history and urianalysis (qualitative test, Dill & Glazko) and these patients were given CQ; the other 27 had taken CQ before and received SP. RESULTS: Combined R-II and R-III CQ-resistance was 58% (60% in under-fives), which is the range previously reported from Zambia. By contrast, SP-resistance (R-II and R-III) was much higher (26%) than previously reported (3% - 17%). The history of prior CQ intake correlated well with the results of the Dill-Glazko test; there was no evidence for prior SP intake to explain these results. CONCLUSION: If our findings of SP resistance are confirmed, other drugs such as quinine, atovaquone/proguanil and artemisinin are required to treat malaria in Zambia.

Author(s): 
Bijl, H. M.
Kager, J.
Koetsier, D. W.
van der Werf, T. S.
Item Type: 
Journal Article
Publication Title: 
Tropical medicine & international health: TM & IH
Journal Abbreviation: 
Trop. Med. Int. Health
Publication Date: 
Oct-00
Publication Year: 
2000
Pages: 
692-695
Volume: 
5
Issue: 
10
ISSN: 
1360-2276
Library Catalog: 
PubMed
Extra: 
PMID: 11044263

Turabian/Chicago Citation

H. M. Bijl, J. Kager, D. W. Koetsier and T. S. van der Werf. Oct-00. "Chloroquine- and sulfadoxine-pyrimethamine-resistant Falciparum malaria in vivo - a pilot study in rural Zambia." Tropical medicine & international health: TM & IH 5: 10: 692-695.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1360-2276 | volume = 5 | pages = 692-695 | last = Bijl | first = H. M. | coauthors = Kager, J., Koetsier, D. W., van der Werf, T. S. | title = Chloroquine- and sulfadoxine-pyrimethamine-resistant Falciparum malaria in vivo - a pilot study in rural Zambia | journal = Tropical medicine & international health: TM & IH | date = Oct-00 | pmid = | pmc = }} </ref>