Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
Language: 
English
Abstract: 

Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance. Here, we provide conclusive evidence that mutant haplotypes of the pfcrt gene product of Asian, African, or South American origin confer chloroquine resistance with characteristic verapamil reversibility and reduced chloroquine accumulation. pfcrt mutations increased susceptibility to artemisinin and quinine and minimally affected amodiaquine activity; hence, these antimalarials warrant further investigation as agents to control chloroquine-resistant falciparum malaria.

Author(s): 
Sidhu, Amar Bir Singh
Verdier-Pinard, Dominik
Fidock, David A.
Item Type: 
Journal Article
Publication Title: 
Science (New York, N.Y.)
Journal Abbreviation: 
Science
Publication Date: 
10/4/2002
Publication Year: 
2002
Pages: 
210-213
Volume: 
298
Issue: 
5591
ISSN: 
1095-9203
DOI: 
10.1126/science.1074045
Library Catalog: 
PubMed
Extra: 
PMID: 12364805 PMCID: PMC2954758

Turabian/Chicago Citation

Amar Bir Singh Sidhu, Dominik Verdier-Pinard and David A. Fidock. 10/4/2002. "Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations." Science (New York, N.Y.) 298: 5591: 210-213. 10.1126/science.1074045.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1126/science.1074045 | issn = 1095-9203 | volume = 298 | pages = 210-213 | last = Sidhu | first = Amar Bir Singh | coauthors = Verdier-Pinard, Dominik, Fidock, David A. | title = Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations | journal = Science (New York, N.Y.) | date = 10/4/2002 | pmid = | pmc = }} </ref>