Chronic caloric restriction alters muscle membrane fatty acid content
Language: 
English
Abstract: 

Chronic caloric restriction (CR) has been demonstrated to increase longevity in lower species and studies are ongoing to evaluate its effect in higher species. A consistent metabolic feature of CR is improved insulin sensitivity and lowered lifetime glycemia, yet the mechanism responsible is currently unknown. However, the membrane's physiochemical properties, as determined by phospholipid composition, have been related to insulin action in animal and human studies and CR has been reported to alter membrane lipid content. We evaluated muscle membrane fatty acid content in rodents randomized to CR versus control diets for up to 29 months. CR was observed to increase the membrane content of C22:6 (docosahexaenoate) and to decrease C18:2 content. The membrane lipid content was related to insulin levels but not to parameters assessing glycemic control. This study suggests that membrane lipids, in particular 22:6, may contribute to the variation in insulin sensitivity seen with age.

Author(s): 
Cefalu, W. T.
Wang, Z. Q.
Bell-Farrow, A. D.
Terry, J. G.
Sonntag, W.
Waite, M.
Parks, J.
Item Type: 
Journal Article
Publication Title: 
Experimental Gerontology
Journal Abbreviation: 
Exp. Gerontol.
Publication Date: 
2000-05
Publication Year: 
2000
Pages: 
331-341
Volume: 
35
Issue: 
3
ISSN: 
0531-5565
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 10832054

Turabian/Chicago Citation

W. T. Cefalu, Z. Q. Wang, A. D. Bell-Farrow, J. G. Terry, W. Sonntag, M. Waite and J. Parks. 2000-05. "Chronic caloric restriction alters muscle membrane fatty acid content." Experimental Gerontology 35: 3: 331-341.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0531-5565 | volume = 35 | pages = 331-341 | last = Cefalu | first = W. T. | coauthors = Wang, Z. Q., Bell-Farrow, A. D., Terry, J. G., Sonntag, W., Waite, M., Parks, J. | title = Chronic caloric restriction alters muscle membrane fatty acid content | journal = Experimental Gerontology | date = 2000-05 | pmid = | pmc = }} </ref>