Clinical trials in fibrositis: a critical review and future directions
Language: 
English
Short Title: 
Clinical trials in fibrositis
Abstract: 

A critical appraisal of the design of clinical trials which examined the effectiveness of various interventions in fibrositis was conducted. Therapeutic interventions included physical fitness, biofeedback, acupuncture, dothiepin, imipramine, cyclobenzaprine, S-adenosylmethionine and amitriptyline. The design and analysis of the randomized, controlled studies render their results reliable. Major areas for methodologic improvement in future trials were identified. Standardized, validated and reliable diagnostic and outcome criteria need to be established. Factors which could predict response need to be identified to enable the selection of the most appropriate patient population for inclusion in future studies. Finally, the incorporation of measures of patient function will result in more clinically meaningful outcome evaluation.

Author(s): 
Gabriel, S. E.
Bombardier, C.
Item Type: 
Journal Article
Publication Title: 
The Journal of Rheumatology. Supplement
Journal Abbreviation: 
J Rheumatol Suppl
Publication Date: 
1989-11
Publication Year: 
1989
Pages: 
177-179
Volume: 
19
ISSN: 
0380-0903
Library Catalog: 
PubMed
Extra: 
PMID: 2691677

Turabian/Chicago Citation

S. E. Gabriel and C. Bombardier. 1989-11. "Clinical trials in fibrositis: a critical review and future directions." The Journal of Rheumatology. Supplement 19: 177-179.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0380-0903 | volume = 19 | pages = 177-179 | last = Gabriel | first = S. E. | coauthors = Bombardier, C. | title = Clinical trials in fibrositis: a critical review and future directions | journal = The Journal of Rheumatology. Supplement | date = 1989-11 | pmid = | pmc = }} </ref>