CLK-1/Coq7p is a DMQ mono-oxygenase and a new member of the di-iron carboxylate protein family
Language: 
English
Abstract: 

Strains of Caenorhabditis elegans mutant for clk-1 exhibit a 20-40% increase in mean lifespan. clk-1 encodes a mitochondrial protein thought to be either an enzyme or regulatory molecule acting within the ubiquinone biosynthesis pathway. Here CLK-1 is shown to be related to the ubiquinol oxidase, alternative oxidase, and belong to the functionally diverse di-iron-carboxylate protein family which includes bacterioferritin and methane mono-oxygenase. Construction and analysis of a homology model indicates CLK-1 is a 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone mono-oxygenase as originally predicted. Analysis of known CLK-1/Coq7p mutations also supports this notion. These findings raise the possibility of developing CLK-1-specific inhibitors to test for lifespan extension in higher organisms.

Author(s): 
Rea, S.
Item Type: 
Journal Article
Publication Title: 
FEBS letters
Journal Abbreviation: 
FEBS Lett.
Publication Date: 
12/14/2001
Publication Year: 
2001
Pages: 
389-394
Volume: 
509
Issue: 
3
ISSN: 
0014-5793
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 11749961

Turabian/Chicago Citation

S. Rea. 12/14/2001. "CLK-1/Coq7p is a DMQ mono-oxygenase and a new member of the di-iron carboxylate protein family." FEBS letters 509: 3: 389-394.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0014-5793 | volume = 509 | pages = 389-394 | last = Rea | first = S. | coauthors = | title = CLK-1/Coq7p is a DMQ mono-oxygenase and a new member of the di-iron carboxylate protein family | journal = FEBS letters | date = 12/14/2001 | pmid = | pmc = }} </ref>