Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling
Language: 
English
Abstract: 

Multiple pathways converge to result in the overexpression of T(h)17 cells in the absence of either vitamin D or the vitamin D receptor (VDR). CD4(+) T cells from VDR knockout (KO) mice have a more activated phenotype than their wild-type (WT) counterparts and readily develop into T(h)17 cells under a variety of in vitro conditions. Vitamin D-deficient CD4(+) T cells also overproduced IL-17 in vitro and 1,25 dihydroxyvitamin D(3) inhibited the development of T(h)17 cells in CD4(+) T-cell cultures. Conversely, the induction of inducible (i) Tregs was lower in VDR KO CD4(+) T cells than WT and the VDR KO iTregs were refractory to IL-6 inhibition. Host-specific effects of the VDR were evident on in vivo development of naive T cells. Development of naive WT CD4(+) T cells in the VDR KO host resulted in the overexpression of IL-17 and more severe experimental inflammatory bowel disease (IBD). The increased expression of T(h)17 cells in the VDR KO mice was associated with a reduction in tolerogenic CD103(+) dendritic cells. The data collectively demonstrate that T(h)17 and iTreg cells are direct and indirect targets of vitamin D. The increased propensity for development of T(h)17 cells in the VDR KO host results in more severe IBD.

Author(s): 
Bruce, Danny
Yu, Sanhong
Ooi, Jot Hui
Cantorna, Margherita T.
Item Type: 
Journal Article
Publication Title: 
International Immunology
Journal Abbreviation: 
Int. Immunol.
Publication Date: 
Aug 2011
Publication Year: 
2011
Pages: 
519-528
Volume: 
23
Issue: 
8
ISSN: 
1460-2377
DOI: 
10.1093/intimm/dxr045
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 21697289 PMCID: PMC3139478

Turabian/Chicago Citation

Danny Bruce, Sanhong Yu, Jot Hui Ooi and Margherita T. Cantorna. Aug 2011. "Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling." International Immunology 23: 8: 519-528. 10.1093/intimm/dxr045.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1093/intimm/dxr045 | issn = 1460-2377 | volume = 23 | pages = 519-528 | last = Bruce | first = Danny | coauthors = Yu, Sanhong, Ooi, Jot Hui, Cantorna, Margherita T. | title = Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling | journal = International Immunology | date = Aug 2011 | pmid = | pmc = }} </ref>