A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis
Language: 
English
Abstract: 

Cytokines are immune mediators that play an important role in the pathogenesis of rheumatoid arthritis (RA), an autoimmune disease that targets the synovial joints. The cytokine environment in the peripheral lymphoid tissues and the target organ (the joint) has a strong influence on the outcome of the initial events that trigger autoimmune inflammation. In susceptible individuals, these events drive inflammation and tissue damage in the joints. However, in resistant individuals, the inflammatory events are controlled effectively with minimal or no overt signs of arthritis. Animal models of human RA have permitted comprehensive investigations into the role of cytokines in the initiation, progression, and recovery phases of autoimmune arthritis. The discovery of interleukin-17 (IL-17) and its association with inflammation and autoimmune pathology has reshaped our viewpoint regarding the pathogenesis of arthritis, which previously was based on a simplistic T helper 1 (Th1)-Th2 paradigm. This review discusses the role of the newer cytokines, particularly those associated with the IL-17/IL-23 axis in arthritis. Also presented herein is the emerging information on IL-32, IL-33, and IL-35. Ongoing studies examining the role of the newer cytokines in the disease process would improve understanding of RA as well as the development of novel cytokine inhibitors that might be more efficacious than the currently available options.

Author(s): 
Astry, Brian
Harberts, Erin
Moudgil, Kamal D.
Item Type: 
Journal Article
Publication Title: 
Journal of Interferon & Cytokine Research: The Official Journal of the International Society for Interferon and Cytokine Research
Journal Abbreviation: 
J. Interferon Cytokine Res.
Publication Date: 
Dec 2011
Publication Year: 
2011
Pages: 
927-940
Volume: 
31
Issue: 
12
ISSN: 
1557-7465
DOI: 
10.1089/jir.2011.0094
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22149412 PMCID: PMC3234492

Turabian/Chicago Citation

Brian Astry, Erin Harberts and Kamal D. Moudgil. Dec 2011. "A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis." Journal of Interferon & Cytokine Research: The Official Journal of the International Society for Interferon and Cytokine Research 31: 12: 927-940. 10.1089/jir.2011.0094.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1089/jir.2011.0094 | issn = 1557-7465 | volume = 31 | pages = 927-940 | last = Astry | first = Brian | coauthors = Harberts, Erin, Moudgil, Kamal D. | title = A cytokine-centric view of the pathogenesis and treatment of autoimmune arthritis | journal = Journal of Interferon & Cytokine Research: The Official Journal of the International Society for Interferon and Cytokine Research | date = Dec 2011 | pmid = | pmc = }} </ref>