A cytokine study in children and adolescents with Tourette's disorder

BACKGROUND: While immune system dysregulation has been postulated to play a role in Tourette's disorder (TD), most research has focused on the hypothesis of an autoimmune process similar to rheumatic fever. This study examined the potential role of cytokines, modulators of the immune system. We hypothesized that children with TD would have increased levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-12, IL-1 beta and IL-6, and decreased IL-2. We also explored whether comorbid obsessive compulsive disorder (OCD) had an effect on the cytokine profile of TD patients. METHOD: Thirty-two children and adolescents with TD (27 males, ages 7-18 years), 17 with comorbid OCD (14 males), and 16 healthy comparison subjects (7 males, ages 9-19), were enrolled. Plasma cytokines were examined using an enzyme-linked immunosorbent assay. The Mann-Whitney and binary logistic regression tests were used to compare the groups. RESULTS: Only patients with comorbid OCD (TD+OCD; n=17) had significantly elevated IL-12 plasma levels compared to controls (2.73+/-5.12 pg/ml vs. 0.55+/-0.88 pg/ml, rank statistic=222.5; p<0.04). IL-2 was significantly higher in the TD+OCD subgroup compared to the non-OCD TD subgroup (0.74+/-0.29 pg/ml vs. 0.49+/-0.24 pg/ml, rank statistics=108.5; p<0.03). There were no other significant cytokine differences between groups. CONCLUSIONS: Findings suggest a role for IL-12 and IL-2 in TD, and that the TD+OCD subgroup may involve different neuroimmunological functions than the TD-OCD subgroup. Larger studies with medication-free patients should follow.

Gabbay, Vilma
Coffey, Barbara J.
Guttman, Leah E.
Gottlieb, Lev
Katz, Yisrael
Babb, James S.
Hamamoto, Mia M.
Gonzalez, Charles J.
Item Type: 
Journal Article
Publication Title: 
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Journal Abbreviation: 
Prog. Neuropsychopharmacol. Biol. Psychiatry
Publication Date: 
Aug 31, 2009
Publication Year: 
Library Catalog: 
NCBI Published Medical (?)
PMID: 19427348 PMCID: PMC2770728

Turabian/Chicago Citation

Vilma Gabbay, Barbara J. Coffey, Leah E. Guttman, Lev Gottlieb, Yisrael Katz, James S. Babb, Mia M. Hamamoto and Charles J. Gonzalez. Aug 31, 2009. "A cytokine study in children and adolescents with Tourette's disorder." Progress in Neuro-Psychopharmacology & Biological Psychiatry 33: 6: 967-971. 10.1016/j.pnpbp.2009.05.001.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.pnpbp.2009.05.001 | issn = 1878-4216 | volume = 33 | pages = 967-971 | last = Gabbay | first = Vilma | coauthors = Coffey, Barbara J., Guttman, Leah E., Gottlieb, Lev, Katz, Yisrael, Babb, James S., Hamamoto, Mia M., Gonzalez, Charles J. | title = A cytokine study in children and adolescents with Tourette's disorder | journal = Progress in Neuro-Psychopharmacology & Biological Psychiatry | date = Aug 31, 2009 | pmid = | pmc = }} </ref>