Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice
Language: 
English
Abstract: 

Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Female DGAT1-deficient mice were protected from age-related increases in body fat, tissue triglycerides, and inflammation in white adipose tissue. This protection was accompanied by increased mean and maximal life spans of ~25% and ~10%, respectively. Middle-agedDgat1-/- mice exhibited several features associated with longevity, including decreased levels of circulating insulin growth factor 1 (IGF1) and reduced fecundity. Thus, deletion of DGAT1 in mice provides a model of leanness and extended lifespan that is independent of calorie restriction.

Author(s): 
Streeper, Ryan S.
Grueter, Carrie A.
Salomonis, Nathan
Cases, Sylvaine
Levin, Malin C.
Koliwad, Suneil K.
Zhou, Ping
Hirschey, Mattew D.
Verdin, Eric
Farese, Robert V.
Item Type: 
Journal Article
Publication Title: 
Aging
Journal Abbreviation: 
Aging (Albany NY)
Publication Date: 
2012-01
Publication Year: 
2012
Pages: 
13-27
Volume: 
4
Issue: 
1
ISSN: 
1945-4589
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22291164 PMCID: PMC3292902

Turabian/Chicago Citation

Ryan S. Streeper, Carrie A. Grueter, Nathan Salomonis, Sylvaine Cases, Malin C. Levin, Suneil K. Koliwad, Ping Zhou, Mattew D. Hirschey, Eric Verdin and Robert V. Farese. 2012-01. "Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice." Aging 4: 1: 13-27.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 1945-4589 | volume = 4 | pages = 13-27 | last = Streeper | first = Ryan S. | coauthors = Grueter, Carrie A., Salomonis, Nathan, Cases, Sylvaine, Levin, Malin C., Koliwad, Suneil K., Zhou, Ping, Hirschey, Mattew D., Verdin, Eric, Farese, Robert V. | title = Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice | journal = Aging | date = 2012-01 | pmid = | pmc = }} </ref>