Demonstration of nondeclarative sequence learning in mice: development of an animal analog of the human serial reaction time task
Language: 
English
Short Title: 
Demonstration of nondeclarative sequence learning in mice
Abstract: 

In this paper, we demonstrate nondeclarative sequence learning in mice using an animal analog of the human serial reaction time task (SRT) that uses a within-group comparison of behavior in response to a repeating sequence versus a random sequence. Ten female B6CBA mice performed eleven 96-trial sessions containing 24 repetitions of a 4-trial sequence. During the 12th session, the repeating sequence was replaced with the random sequence halfway through the session. Reaction time (RT) to respond to an illuminated nose-poke was recorded, and performance was compared at the halfway point in each session to test for any change in behavior. For learning effect, RTs decreased over the no-switch repeating-sequence sessions. For interference effect, behavior did not change appreciably at the halfway point during the last repeating-sequence session. However, RTs deteriorated significantly after the switch from repeating to random sequences halfway through session 12. The mice demonstrated a robust interference effect when switched from repeating to random sequences. This pattern of behavior in humans performing the SRT is interpreted as evidence of nondeclarative sequence learning. The similarity between the human and mouse SRTs will enable more direct comparisons of mouse-human nondeclarative memory behavior and will provide a useful behavioral end-point in mouse-models of basal ganglia dysfunction.

Author(s): 
Christie, Michael A.
Hersch, Steven M.
Item Type: 
Journal Article
Publication Title: 
Learning & Memory (Cold Spring Harbor, N.Y.)
Journal Abbreviation: 
Learn. Mem.
Publication Date: 
2004 Nov-Dec
Publication Year: 
2004
Pages: 
720-723
Volume: 
11
Issue: 
6
ISSN: 
1072-0502
DOI: 
10.1101/lm.85404
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 15537741

Turabian/Chicago Citation

Michael A. Christie and Steven M. Hersch. 2004 Nov-Dec. "Demonstration of nondeclarative sequence learning in mice: development of an animal analog of the human serial reaction time task." Learning & Memory (Cold Spring Harbor, N.Y.) 11: 6: 720-723. 10.1101/lm.85404.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1101/lm.85404 | issn = 1072-0502 | volume = 11 | pages = 720-723 | last = Christie | first = Michael A. | coauthors = Hersch, Steven M. | title = Demonstration of nondeclarative sequence learning in mice: development of an animal analog of the human serial reaction time task | journal = Learning & Memory (Cold Spring Harbor, N.Y.) | date = 2004 Nov-Dec | pmid = | pmc = }} </ref>