Depression gets old fast: do stress and depression accelerate cell aging?
Language: 
English
Short Title: 
Depression gets old fast
Abstract: 

Depression has been likened to a state of "accelerated aging," and depressed individuals have a higher incidence of various diseases of aging, such as cardiovascular and cerebrovascular diseases, metabolic syndrome, and dementia. Chronic exposure to certain interlinked biochemical pathways that mediate stress-related depression may contribute to "accelerated aging," cell damage, and certain comorbid medical illnesses. Biochemical mediators explored in this theoretical review include the hypothalamic-pituitary-adrenal axis (e.g., hyper- or hypoactivation of glucocorticoid receptors), neurosteroids, such as dehydroepiandrosterone and allopregnanolone, brain-derived neurotrophic factor, excitotoxicity, oxidative and inflammatory stress, and disturbances of the telomere/telomerase maintenance system. A better appreciation of the role of these mediators in depressive illness could lead to refined models of depression, to a re-conceptualization of depression as a whole body disease rather than just a "mental illness," and to the rational development of new classes of medications to treat depression and its related medical comorbidities.

Author(s): 
Wolkowitz, Owen M.
Epel, Elissa S.
Reus, Victor I.
Mellon, Synthia H.
Item Type: 
Journal Article
Publication Title: 
Depression and Anxiety
Journal Abbreviation: 
Depress Anxiety
Publication Date: 
2010-04
Publication Year: 
2010
Pages: 
327-338
Volume: 
27
Issue: 
4
ISSN: 
1520-6394
DOI: 
10.1002/da.20686
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 20376837

Turabian/Chicago Citation

Owen M. Wolkowitz, Elissa S. Epel, Victor I. Reus and Synthia H. Mellon. 2010-04. "Depression gets old fast: do stress and depression accelerate cell aging?." Depression and Anxiety 27: 4: 327-338. 10.1002/da.20686.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1002/da.20686 | issn = 1520-6394 | volume = 27 | pages = 327-338 | last = Wolkowitz | first = Owen M. | coauthors = Epel, Elissa S., Reus, Victor I., Mellon, Synthia H. | title = Depression gets old fast: do stress and depression accelerate cell aging? | journal = Depression and Anxiety | date = 2010-04 | pmid = | pmc = }} </ref>