Determining the precise cerebral response to acupuncture: an improved FMRI study
Language: 
English
Short Title: 
Determining the precise cerebral response to acupuncture
Abstract: 

BACKGROUND: In acupuncture brain imaging trials, there are many non-acupuncture factors confounding the neuronal mapping. The modality of the placebo, subjects' psychological attitude to acupuncture and their physical state are the three most confounding factors. OBJECTIVE: To obtain more precise and accurate cerebral fMRI mapping of acupuncture. DESIGN AND SETTING: A 2×2 randomized, controlled, participant-blinded cross-over factorial acupuncture trial was conducted at Xuanwu Hospital in Beijing, China. PARTICIPANTS: Forty-one college students with myopia were recruited to participate in our study and were allocated randomly to four groups, Group A, Group B, Group C and Group D. INTERVENTIONS: Group A received real acupuncture (RA) and treatment instruction (TI); Group B received RA and non-treatment instruction (NI); Group C received sham acupuncture (SA) and TI; Group D received SA and NI. RESULTS: Stimulation at LR3 activated some areas of the visual cortex, and the cerebral response to non-acupuncture factors was complex and occurred in multiple areas. CONCLUSIONS: The results provide more evidence regarding the credibility of acupuncture therapy and suggest that more precise experimental designs are needed to eliminate sources of bias in acupuncture controlled trials and to obtain sound results.

Author(s): 
Liu, Hua
Xu, Jianyang
Shan, Baoci
Li, Yongzhong
Li, Lin
Xue, Jingquan
Nie, Binbin
Item Type: 
Journal Article
Publication Title: 
PloS One
Journal Abbreviation: 
PLoS ONE
Publication Date: 
2012
Publication Year: 
2012
Pages: 
e49154
Volume: 
7
Issue: 
11
ISSN: 
1932-6203
DOI: 
10.1371/journal.pone.0049154
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23152865 PMCID: PMC3494684

Turabian/Chicago Citation

Hua Liu, Jianyang Xu, Baoci Shan, Yongzhong Li, Lin Li, Jingquan Xue and Binbin Nie. 2012. "Determining the precise cerebral response to acupuncture: an improved FMRI study." PloS One 7: 11: e49154. 10.1371/journal.pone.0049154.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1371/journal.pone.0049154 | issn = 1932-6203 | volume = 7 | pages = e49154 | last = Liu | first = Hua | coauthors = Xu, Jianyang, Shan, Baoci, Li, Yongzhong, Li, Lin, Xue, Jingquan, Nie, Binbin | title = Determining the precise cerebral response to acupuncture: an improved FMRI study | journal = PloS One | date = 2012 | pmid = | pmc = }} </ref>