Diet calcium level but not calcium supplement particle size affects bone density and mechanical properties in ovariectomized rats
Language: 
English
Abstract: 

Calcium (Ca) supplements, especially Ca carbonate (CaCO3), are the main alternative sources of dietary Ca and an important part of a treatment regimen for osteoporosis, the most common metabolic bone disorder of aging and menopause. In a female ovariectomized (OVX) rat model for studying postmenopausal osteoporosis, we tested the hypothesis that a small compared with a large particle size of CaCO3 (13.0- vs. 18.5-mum geometric diameter) would result in increased Ca balance and subsequently bone mass and that this would be affected by dietary Ca level. We used 6-mo-old rats that were OVX either at 6 or 3 mo of age as models of early or stable menopausal status, respectively. The rats received semipurified diets that contained either 0.4 or 0.2% dietary Ca provided from CaCO3 of 2 particle sizes. A group of Sham-operated rats with intact ovaries served as control and were fed 0.4% dietary Ca from large particles. Estrogen deficiency as a result of ovariectomy had an adverse effect on bone density, mineral content, and bone mechanical properties (P < 0.001). Reducing dietary Ca from 0.4 to 0.2% resulted in significant adverse effects on bone density and mechanical properties (P < 0.001). The particle size of CaCO3 did not affect total Ca balance, bone dual energy X-ray absorptiometry and peripheral quantitative computed tomography indices, bone ash and Ca content, or the mechanical determinants of bone strength. We conclude that a decrease in particle size of CaCO3 to 70% of that typically found in Ca supplements does not provide a benefit to overall Ca metabolism or bone characteristics and that the amount of Ca consumed is of greater influence in enhancing Ca nutrition and skeletal strength.

Author(s): 
Shahnazari, Mohammad
Martin, Berdine R.
Legette, LeeCole L.
Lachcik, Pamela J.
Welch, Jo
Weaver, Connie M.
Item Type: 
Journal Article
Publication Title: 
The Journal of Nutrition
Journal Abbreviation: 
J. Nutr.
Publication Date: 
Jul 2009
Publication Year: 
2009
Pages: 
1308-1314
Volume: 
139
Issue: 
7
ISSN: 
1541-6100
DOI: 
10.3945/jn.108.101071
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 19474156

Turabian/Chicago Citation

Mohammad Shahnazari, Berdine R. Martin, LeeCole L. Legette, Pamela J. Lachcik, Jo Welch and Connie M. Weaver. Jul 2009. "Diet calcium level but not calcium supplement particle size affects bone density and mechanical properties in ovariectomized rats." The Journal of Nutrition 139: 7: 1308-1314. 10.3945/jn.108.101071.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.3945/jn.108.101071 | issn = 1541-6100 | volume = 139 | pages = 1308-1314 | last = Shahnazari | first = Mohammad | coauthors = Martin, Berdine R., Legette, LeeCole L., Lachcik, Pamela J., Welch, Jo, Weaver, Connie M. | title = Diet calcium level but not calcium supplement particle size affects bone density and mechanical properties in ovariectomized rats | journal = The Journal of Nutrition | date = Jul 2009 | pmid = | pmc = }} </ref>