Diet-induced developmental acceleration independent of TOR and insulin in C. elegans
Language: 
English
Abstract: 

Dietary composition has major effects on physiology. Here, we show that developmental rate, reproduction, and lifespan are altered in C.†elegans fed Comamonas DA1877 relative to those fed a standard E.†coli OP50 diet. We identify a set of genes that change in expression in response to this diet and use the promoter of one of these (acdh-1) as a dietary sensor. Remarkably, the effects on transcription and†development occur even when Comamonas DA1877 is diluted with another diet, suggesting that Comamonas DA1877 generates a signal that is sensed by the nematode. Surprisingly, the developmental effect is independent from TOR and insulin signaling. Rather, Comamonas DA1877 affects cyclic gene expression during molting, likely through the nuclear hormone receptor NHR-23. Altogether, our findings indicate that different bacteria elicit various responses via distinct mechanisms, which has implications for diseases such as obesity and the interactions between the human microbiome and intestinal cells.

Author(s): 
MacNeil, Lesley T.
Watson, Emma
Arda, H. Efsun
Zhu, Lihua Julie
Walhout, Albertha J. M.
Item Type: 
Journal Article
Publication Title: 
Cell
Journal Abbreviation: 
Cell
Publication Date: 
3/28/2013
Publication Year: 
2013
Pages: 
240-252
Volume: 
153
Issue: 
1
ISSN: 
1097-4172
DOI: 
10.1016/j.cell.2013.02.049
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 23540701 PMCID: PMC3821073

Turabian/Chicago Citation

Lesley T. MacNeil, Emma Watson, H. Efsun Arda, Lihua Julie Zhu and Albertha J. M. Walhout. 3/28/2013. "Diet-induced developmental acceleration independent of TOR and insulin in C. elegans." Cell 153: 1: 240-252. 10.1016/j.cell.2013.02.049.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1016/j.cell.2013.02.049 | issn = 1097-4172 | volume = 153 | pages = 240-252 | last = MacNeil | first = Lesley T. | coauthors = Watson, Emma, Arda, H. Efsun, Zhu, Lihua Julie, Walhout, Albertha J. M. | title = Diet-induced developmental acceleration independent of TOR and insulin in C. elegans | journal = Cell | date = 3/28/2013 | pmid = | pmc = }} </ref>