Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer
Language: 
English
Abstract: 

The inverse correlation between levels of dietary calcium and colorectal cancer (CRC) incidence has been extensively investigated. However, the impact of supplemental calcium on cancer therapy remains unknown. We used four models of CRC, Caco-2 and HCT116 human cancer cell lines and Apc (Min/+) and azoxymethane carcinogen-induced mouse models, to investigate the impact of a western-style diet low in calcium (0.05%) vs. a similar diet but supplemented with calcium (5%) on therapeutic targeting of the epidermal growth factor receptor (EGFR). We found that calcium supplementation combined with pharmacologic blockade of EGFR results in an additive effect on tumor growth inhibition in all models. Unexpectedly, the combined use of dietary calcium supplementation and EGFR inhibitors also resulted in elevated toxicity suggesting that careful consideration be given when combining dietary supplements with prescribed cancer therapies.

Author(s): 
Rinella, Erica S.
Bankaitis, Eric D.
Threadgill, David W.
Item Type: 
Journal Article
Publication Title: 
Cancer Biology & Therapy
Journal Abbreviation: 
Cancer Biol. Ther.
Publication Date: 
Feb 1, 2012
Publication Year: 
2012
Pages: 
130-137
Volume: 
13
Issue: 
3
ISSN: 
1555-8576
DOI: 
10.4161/cbt.13.3.18690
Library Catalog: 
NCBI Published Medical (?)
Extra: 
PMID: 22231407 PMCID: PMC3336070

Turabian/Chicago Citation

Erica S. Rinella, Eric D. Bankaitis and David W. Threadgill. Feb 1, 2012. "Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer." Cancer Biology & Therapy 13: 3: 130-137. 10.4161/cbt.13.3.18690.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.4161/cbt.13.3.18690 | issn = 1555-8576 | volume = 13 | pages = 130-137 | last = Rinella | first = Erica S. | coauthors = Bankaitis, Eric D., Threadgill, David W. | title = Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer | journal = Cancer Biology & Therapy | date = Feb 1, 2012 | pmid = | pmc = }} </ref>