Diuretic effect of sodium artesunate in patients with malaria
Language: 
English
Abstract: 

Previously, we described a direct inhibitory effect of sodium artesunate on sodium chloride transport in the thick ascending limb of Henle's loop, indicating that artesunate acts as a diuretic agent. Here we present 2 cases of falciparum malaria treated with 4 intravenous 60-mg doses of sodium artesunate. Neither diuretics nor vasoactive drugs were administered. A rise in diuresis (6 L/24 hours) was accompanied by an increase in natriuresis, and both declined at the end of the treatment. This diuretic effect has not been reported previously in patients and may modify the course of renal failure and respiratory distress syndrome, both of which complicate severe malaria.

Author(s): 
Seguro, Antonio Carlos
Campos, Silvia Bernardete
Item Type: 
Journal Article
Publication Title: 
The American Journal of Tropical Medicine and Hygiene
Journal Abbreviation: 
Am. J. Trop. Med. Hyg.
Publication Date: 
11/2/2015
Publication Year: 
2002
Pages: 
473-474
Volume: 
67
Issue: 
5
ISSN: 
0002-9637
Library Catalog: 
PubMed
Extra: 
PMID: 12479546

Turabian/Chicago Citation

Antonio Carlos Seguro and Silvia Bernardete Campos. 11/2/2015. "Diuretic effect of sodium artesunate in patients with malaria." The American Journal of Tropical Medicine and Hygiene 67: 5: 473-474.

Wikipedia Citation

<ref> {{Cite journal | doi = | issn = 0002-9637 | volume = 67 | pages = 473-474 | last = Seguro | first = Antonio Carlos | coauthors = Campos, Silvia Bernardete | title = Diuretic effect of sodium artesunate in patients with malaria | journal = The American Journal of Tropical Medicine and Hygiene | date = 11/2/2015 | pmid = | pmc = }} </ref>