DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer
Short Title: 
DM235 (sunifiram)

DM235 (sunifiram), a new compound structurally related to piracetam, prevented the amnesia induced by scopolamine (1.5 mg kg(-1) i.p.), after intraperitoneal (0.001-0.1 mg kg(-1)) or oral (0.01-0.1 mg kg(-1)) administration, as shown by a passive avoidance test in mice. The antiamnesic effect of DM235 was comparable to that of well-known nootropic drugs such as piracetam (30-100 mg kg(-1) i.p.), aniracetam (100 mg kg(-1) p.o.) or rolipram (30 mg kg(-1) p.o.). DM235 also prevented mecamylamine (20 mg kg(-1) i.p.)-, baclofen (2 mg kg(-1) i.p.)- and clonidine (0.125 mg kg(-1) i.p.)-induced amnesia in the same test. In the Morris water maze test with rats, scopolamine (0.8 mg kg(-1) i.p.) inhibited the reduction of escape latency in both acquisition and retention/retraining tests. DM235 (0.1 mg kg(-1) i.p.), 20 min before each daily acquisition training, prevented the scopolamine-induced memory impairment. DM235 (1 mg kg(-1) i.p.) also reduced the duration of pentobarbitone-induced hypnosis in mice without modifying the induction time of hypnosis. At the highest effective doses, the investigated compound neither impaired motor coordination (rota-rod test), nor modified spontaneous motility and inspection activity (Animex and hole board tests). These results indicate that DM235, a compound structurally related to piracetam, is a novel nootropic endowed with the capability to prevent cognitive deficits at very low doses. Indeed, its potency is about 1,000 times higher than that of the most active piracetam-like compounds.

Ghelardini, C.
Galeotti, N.
Gualtieri, F.
Romanelli, M. N.
Bucherelli, C.
Baldi, E.
Bartolini, A.
Item Type: 
Journal Article
Publication Title: 
Naunyn-Schmiedeberg's Archives of Pharmacology
Journal Abbreviation: 
Naunyn Schmiedebergs Arch. Pharmacol.
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Publication Year: 
Library Catalog: 
PMID: 12070754

Turabian/Chicago Citation

C. Ghelardini, N. Galeotti, F. Gualtieri, M. N. Romanelli, C. Bucherelli, E. Baldi and A. Bartolini. 6/2/2015. "DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer." Naunyn-Schmiedeberg's Archives of Pharmacology 365: 6: 419-426. 10.1007/s00210-002-0577-3.

Wikipedia Citation

<ref> {{Cite journal | doi = 10.1007/s00210-002-0577-3 | issn = 0028-1298 | volume = 365 | pages = 419-426 | last = Ghelardini | first = C. | coauthors = Galeotti, N., Gualtieri, F., Romanelli, M. N., Bucherelli, C., Baldi, E., Bartolini, A. | title = DM235 (sunifiram): a novel nootropic with potential as a cognitive enhancer | journal = Naunyn-Schmiedeberg's Archives of Pharmacology | date = 6/2/2015 | pmid = | pmc = }} </ref>